GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization
about
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1The sonic hedgehog-patched-gli pathway in human development and diseaseHuman GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell CarcinomaA potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues.Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3Identification of the gene transcription repressor domain of Gli3The therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyCentrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesisSpecification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarusGli-1 siRNA induced apoptosis in Huh7 cells.Point mutations in GLI3 lead to misregulation of its subcellular localization.Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome.Visualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish.Gli genes in development and cancer.The VACTERL association: lessons from the Sonic hedgehog pathway.Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations.The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; No phenotype prediction from the position of GLI3 mutations.The developmental program of the hypothalamus and its disorders.New insights into genotype-phenotype correlation for GLI3 mutations.The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes.The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.Shadows of complexity: what biological networks reveal about epistasis and pleiotropy.Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathwayIdentification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.What you can learn from one gene: GLI3Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus.Sonic Hedgehog Signaling and VACTERL Association.Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent inteinSomatic mutations in GLI3 and OFD1 involved in sonic hedgehog signaling cause hypothalamic hamartoma.Key mechanisms of early lung development.Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy.Hedgehog-Gli signaling pathway inhibitors as anticancer agents.The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases.Primary cilia in neurodevelopmental disorders.
P2860
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P2860
GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
GLI3 mutations in human disord ...... ein functions and localization
@ast
GLI3 mutations in human disord ...... ein functions and localization
@en
GLI3 mutations in human disord ...... ein functions and localization
@en-gb
GLI3 mutations in human disord ...... ein functions and localization
@nl
type
label
GLI3 mutations in human disord ...... ein functions and localization
@ast
GLI3 mutations in human disord ...... ein functions and localization
@en
GLI3 mutations in human disord ...... ein functions and localization
@en-gb
GLI3 mutations in human disord ...... ein functions and localization
@nl
prefLabel
GLI3 mutations in human disord ...... ein functions and localization
@ast
GLI3 mutations in human disord ...... ein functions and localization
@en
GLI3 mutations in human disord ...... ein functions and localization
@en-gb
GLI3 mutations in human disord ...... ein functions and localization
@nl
P2093
P2860
P3181
P356
P1476
GLI3 mutations in human disord ...... ein functions and localization
@en
P2093
E Lindström
L G Biesecker
P Kogerman
R Toftgárd
P2860
P304
P3181
P356
10.1073/PNAS.96.6.2880
P407
P577
1999-03-16T00:00:00Z