Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
about
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's diseaseThe physiology of protein S-acylationThe canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-AcyltransferasesThe Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activityDysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14)Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14LCuration of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers.Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.Allele-selective inhibition of trinucleotide repeat genes.Memory and synaptic deficits in Hip14/DHHC17 knockout mice.Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases.Targeting protein palmitoylation: selective inhibitors and implications in disease.Protein palmitoylation: Palmitoyltransferases and their specificity.Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.Palmitoylation of caspase-6 by HIP14 regulates its activation.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.
P2860
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P2860
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@ast
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@en
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@nl
type
label
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@ast
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@en
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@nl
prefLabel
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@ast
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@en
Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.
@nl
P2093
P2860
P50
P356
P1476
Wild-type HTT modulates the en ...... al palmitoyl transferase HIP14
@en
P2093
Alaa El-Husseini
Junmei Wan
Liza Sutton
Nicholas G Davis
Rujun Kang
Shaun S Sanders
P2860
P304
P356
10.1093/HMG/DDR242
P577
2011-06-02T00:00:00Z