Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. - Test2 - elhamkhani - TriplyDB

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

http://www.wikidata.org/entity/Q34189409

about

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease The physiology of protein S-acylation The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14)Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers.Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.Allele-selective inhibition of trinucleotide repeat genes.Memory and synaptic deficits in Hip14/DHHC17 knockout mice.Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases.Targeting protein palmitoylation: selective inhibitors and implications in disease.Protein palmitoylation: Palmitoyltransferases and their specificity.Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease.ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.Palmitoylation of caspase-6 by HIP14 regulates its activation.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.

P2860

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P2860

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

http://www.wikidata.org/entity/Q34189409

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

@ast

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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type

label

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

@ast

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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prefLabel

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

@ast

Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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Wild-type HTT modulates the en ...... l palmitoyl transferase HIP14.

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P1433

Human Molecular Genetics

P1476

Wild-type HTT modulates the en ...... al palmitoyl transferase HIP14

@en

P2093

Alaa El-Husseini

http://www.w3.org/2001/XMLSchema#string

Junmei Wan

http://www.w3.org/2001/XMLSchema#string

Kun Huang

http://www.w3.org/2001/XMLSchema#string

Lili Liu

http://www.w3.org/2001/XMLSchema#string

Liza Sutton

http://www.w3.org/2001/XMLSchema#string

Nicholas G Davis

http://www.w3.org/2001/XMLSchema#string

Rujun Kang

http://www.w3.org/2001/XMLSchema#string

Shaun S Sanders

http://www.w3.org/2001/XMLSchema#string

P2860

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.

P304

3356-3365

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scholarly article

P356

10.1093/HMG/DDR242

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P433

17

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P478

20

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P50

Jeffrey B Carroll

Michael R. Hayden

Roshni Singaraja

P577

2011-06-02T00:00:00Z

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51186978

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21636527

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3153302

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