The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. - Test2 - elhamkhani - TriplyDB

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

http://www.wikidata.org/entity/Q34299501

about

New insights into an X-traordinary viral protein Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection The ribonuclease activity of SAMHD1 is required for HIV-1 restriction Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1 Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Development of monoclonal antibodies specifically recognizing the endogenous sterile alpha motif and HD domain 1 protein in porcine cell lines.Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.SAMHD1 specifically restricts retroviruses through its RNase activity.SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.Host restriction factors in retroviral infection: promises in virus-host interaction.Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply Restriction of diverse retroviruses by SAMHD1.Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1 TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes.Host SAMHD1 protein promotes HIV-1 recombination in macrophages.HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.Macaque-tropic human immunodeficiency virus type 1: breaking out of the host restriction factors Degradation of SAMHD1 by Vpx Is Independent of Uncoating.Current views on HIV-1 latency, persistence, and cure.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.

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P2860

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

http://www.wikidata.org/entity/Q34299501

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@ast

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@en

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@nl

type

label

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@ast

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@en

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@nl

prefLabel

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@ast

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@en

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@nl

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P1433

Journal of Virology

P1476

The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.

@en

P2093

Baek Kim

http://www.w3.org/2001/XMLSchema#string

Eric C Logue

http://www.w3.org/2001/XMLSchema#string

Henning Hofmann

http://www.w3.org/2001/XMLSchema#string

Megan L Schultz

http://www.w3.org/2001/XMLSchema#string

Nathaniel R Landau

http://www.w3.org/2001/XMLSchema#string

Nicolin Bloch

http://www.w3.org/2001/XMLSchema#string

Sylvie B Polsky

http://www.w3.org/2001/XMLSchema#string

Waaqo Daddacha

http://www.w3.org/2001/XMLSchema#string

P2860

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency

The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

P304

12552-12560

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scholarly article

P356

10.1128/JVI.01657-12

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P407

P433

23

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P478

86

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P577

2012-09-12T00:00:00Z

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P5875

230843634

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22973040

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3497686

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