A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression - Test2 - elhamkhani - TriplyDB

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

http://www.wikidata.org/entity/Q34324068

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Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 C-terminal phosphorylation controls the stability and function of p27kip1 Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy Foxp3 protein stability is regulated by cyclin-dependent kinase 2 Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2 The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1 Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway.Enhanced proliferation of human skeletal muscle precursor cells derived from elderly donors cultured in estimated physiological (5%) oxygen.Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.JAB1/CSN5: a new player in cell cycle control and cancer Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells.Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Label-retaining, quiescent globose basal cells are found in the olfactory epithelium.Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.Hunk is required for HER2/neu-induced mammary tumorigenesis.p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser¹⁰ p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer.Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma The COP9 signalosome and vascular function: intriguing possibilities?p27kip1: a target for tumor therapies?Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation.

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

http://www.wikidata.org/entity/Q34324068

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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prefLabel

A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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A pathway in quiescent cells t ...... ization, and tumor suppression

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Genes & Development

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A pathway in quiescent cells t ...... ization, and tumor suppression

@en

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Arnaud Besson

http://www.w3.org/2001/XMLSchema#string

Christopher J Kemp

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James M Roberts

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Karen S Kelly-Spratt

http://www.w3.org/2001/XMLSchema#string

Mark Gurian-West

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Xueyan Chen

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P2860

Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

CDK inhibitors: positive and negative regulators of G1-phase progression

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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47-64

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scholarly article

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10.1101/GAD.1384406

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1

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20

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2006-01-01T00:00:00Z

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7380646

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16391232

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1356100

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