p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
about
The F-box protein family.The expression of the ubiquitin ligase subunit Cks1 in human breast cancerThe function of APC/CCdh1 in cell cycle and beyondInsights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complexFbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich regionRegulation of p27 degradation and S-phase progression by Ro52 RING finger proteinA growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressorPhosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phaseMyxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein TobNovel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligaseRole of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestCRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisInteraction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasomeEvidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cellsOncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancerSCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigenSpecific small molecule inhibitors of Skp2-mediated p27 degradationThe adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memoryRole of the F-box protein Skp2 in lymphomagenesisSkp2: a novel potential therapeutic target for prostate cancerPhosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKBCyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerSpy1 interacts with p27Kip1 to allow G1/S progressionRole of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradationDown-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cellsMitf regulation of Dia1 controls melanoma proliferation and invasivenessSCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysisRole of the F-box protein Skp2 in adhesion-dependent cell cycle progressionThe cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.The role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processesThe F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerCombinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p.Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissuesNovel strategies to target the ubiquitin proteasome system in multiple myeloma
P2860
Q21194893-7CF35EE9-9CB9-4C32-976D-186452806C2DQ21195244-1FE1F3B4-9C9D-4322-954C-39D5542B0B1EQ21203555-17AD532A-D3BE-4687-A813-4EC4E36C4EE1Q24290565-2C311487-32D5-48E9-99CA-6CACA61BF014Q24293185-CAE8102A-18D4-4871-9DA4-B31E03DF6221Q24298491-48EF411C-6EF9-4E78-ACBC-D5F355D31B37Q24300746-AFBC2B13-969F-4026-B491-5CBE81A66844Q24301920-7670B1AF-DF47-4FBB-BC1F-37FFA0A482C5Q24309424-037C69C1-B623-4382-B51E-482829BEEE1CQ24311311-F08E87AB-015B-4C18-AC30-3A38523ADD82Q24311841-823BC2AF-F05B-4E4F-809F-6A6BF8853A0CQ24336899-DEBEF7A9-DEF5-4D27-85EE-2E836A1B3955Q24529904-80042BA1-4C12-4DA2-9F38-FAD66A8F60C8Q24534914-96E37596-40D6-4FA1-A15D-39812B835409Q24537257-E1174345-1920-42FA-87DB-74BED0E57D5BQ24540387-13D5BDB2-1468-401E-A5BC-4B218AD8E99EQ24548261-103C5F04-5D5C-4D43-853E-C3258315F03CQ24552563-22E96900-1043-4E26-9851-ECBF6B8AF939Q24553135-21593CBA-13B3-4052-BB96-FE19CFBC34C0Q24556627-6988942E-735B-4B38-8B30-FF1D39A17239Q24596988-004034A6-A53A-41C2-BFCC-10CE0B194D28Q24598286-DC972F89-891F-4E1D-BE13-E1B4FD371772Q24603883-1BB8BAE7-3AEC-47A3-A412-B5A4E1712964Q24625558-C7CD816A-F675-4C03-8D61-0F1C3E47739BQ24634406-3DD1E309-8BA0-4B23-B454-DB79C7D42339Q24646831-20B7B2E3-160D-4E15-B324-B5E99A675AF3Q24648025-9D6732DC-25C1-4697-A9F4-56CEC3905106Q24669675-E2C5713E-B677-4322-8FB2-BEF7A56F24EFQ24669893-95902588-D4C8-4450-AD74-BBC54D920342Q24672087-8CD5226B-D88A-4808-9158-C85F04834B6EQ24672631-98018BBB-32A1-4193-97EF-1206B568436EQ24677035-8AA52B6A-D04E-47B2-8F23-C3AF79F23C7DQ24685645-4C1E9316-1D6E-4FF9-947E-52D4977FD845Q24793380-10BF1751-4667-4F67-AB97-C0177FA6C687Q24794970-E4DC57CA-A582-4ED1-9C7D-E7C9B939424DQ24800464-8A037286-B68B-41D8-838C-69B119ACC6D4Q24803723-7F067FFA-1398-401B-BA33-72F5DDA6B366Q24804754-FC586D45-CC1B-45A3-83F4-F66538859E15Q24806313-FDA429E4-7035-41AB-B602-841CB8DFD00EQ26773246-83E78DA6-0B0B-497B-ADA4-CF0CEF06B5C2
P2860
p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@ast
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@en
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@nl
type
label
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@ast
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@en
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@nl
prefLabel
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@ast
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@en
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@nl
P2093
P3181
P1433
P1476
p27(Kip1) ubiquitination and d ...... h phosphorylated Thr187 in p27
@en
P2093
P304
P3181
P356
10.1016/S0960-9822(99)80290-5
P407
P50
P577
1999-06-01T00:00:00Z