The central region of HDM2 provides a second binding site for p53. - Test2 - elhamkhani - TriplyDB

The central region of HDM2 provides a second binding site for p53.

The central region of HDM2 provides a second binding site for p53.

http://www.wikidata.org/entity/Q34335012

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Turning the RING domain protein MdmX into an active ubiquitin-protein ligase Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage Acetylation is indispensable for p53 activation An essential function of the extreme C-terminus of MDM2 can be provided by MDMX Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2 Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover The structure and interactions of the proline-rich domain of ASPP2 S100 proteins interact with the N-terminal domain of MDM2 Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity In vitro selection of mutant HDM2 resistant to Nutlin inhibition C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53 Modes of p53 regulation Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans.Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53 Making sense of ubiquitin ligases that regulate p53.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Splicing up mdm2 for cancer proteome diversity.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.MDMX contains an autoinhibitory sequence element.Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens Avoiding drug resistance through extended drug target interfaces: a case for stapled peptides Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer.Regulation of p53--insights into a complex process.

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P2860

The central region of HDM2 provides a second binding site for p53.

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2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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prefLabel

The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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The central region of HDM2 provides a second binding site for p53.

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PNAS.0510343103

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Proceedings of the National Academy of Sciences of the United States of America

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The central region of HDM2 provides a second binding site for p53

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Alan R Fersht

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Grace W Yu

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Stefan Freund

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P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

p53, the cellular gatekeeper for growth and division

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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scholarly article

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5

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103

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Dmitry B Veprintsev

Maria R Fernandez-Fernandez

Stefan Rüdiger

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2006-01-23T00:00:00Z

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16432196

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1360574

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