Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
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Post-translational regulation enables robust p53 regulation.MDM2 oligomers: antagonizers of the guardian of the genome.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.Limiting the power of p53 through the ubiquitin proteasome pathway.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in miceIt Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitinationProtein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.ATM phosphorylates MDM2MDM2 forms homo- or heterodimersMDM2 binds TP53MDM2 ubiquitinates TP53Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesisScission of the p53-MDM2 Loop by Ribosomal Proteins.Regulation of MDM2 Stability After DNA Damage.Mouse modelling of the MDM2/MDMX-p53 signalling axis.Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells.Arabidopsis RZFP34/CHYR1, a Ubiquitin E3 Ligase, Regulates Stomatal Movement and Drought Tolerance via SnRK2.6-Mediated Phosphorylation.DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.SMG7 is a critical regulator of p53 stability and function in DNA damage stress response.Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.The Arabidopsis EDR1 protein kinase negatively regulates the ATL1 E3 ubiquitin ligase to suppress cell death.Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.Regulation of TP53 Expression and DegradationRegulation of TP53 DegradationA novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2).BTK blocks the inhibitory effects of MDM2 on p53 activity.Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle.MDM2 homodimers auto-ubiquitinateThe Ubiquitin E3 Ligase PRU1 Regulates WRKY6 Degradation to Modulate Phosphate Homeostasis in Response to Low-Pi Stress in Arabidopsis.
P2860
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P2860
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@ast
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@en
type
label
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@ast
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@en
prefLabel
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@ast
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@en
P2093
P2860
P356
P1476
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.
@en
P2093
Baozong Li
Brittany Cross
Jiandong Chen
Lihong Chen
Qian Cheng
P2860
P304
P356
10.1128/MCB.05553-11
P407
P577
2011-10-10T00:00:00Z