MAFA controls genes implicated in insulin biosynthesis and secretion - Test2 - elhamkhani - TriplyDB

MAFA controls genes implicated in insulin biosynthesis and secretion

MAFA controls genes implicated in insulin biosynthesis and secretion

http://www.wikidata.org/entity/Q34588075

about

Structure, mechanism and regulation of pyruvate carboxylase Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression Generation of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cells Current status of regeneration of pancreatic β-cells Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma Pancreatic beta cells require NeuroD to achieve and maintain functional maturity Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells Luteolin prevents uric acid-induced pancreatic β-cell dysfunction.Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo A small molecule differentiation inducer increases insulin production by pancreatic β cells MafA and MafB regulate genes critical to beta-cells in a unique temporal manner Deconstructing pancreas developmental biology.Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse.Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.Glucagon-like peptide-1 triggers protective pathways in pancreatic beta-cells exposed to glycated serum.Update on the protective molecular pathways improving pancreatic beta-cell dysfunction Glucolipotoxicity: fuel excess and beta-cell dysfunction.The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress.Detection of expressional changes induced by intrauterine growth restriction in the developing rat pancreas.Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase p38 MAPK is a major regulator of MafA protein stability under oxidative stress.Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.

P2860

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P2860

MAFA controls genes implicated in insulin biosynthesis and secretion

http://www.wikidata.org/entity/Q34588075

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

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name

MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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type

label

MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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prefLabel

MAFA controls genes implicated in insulin biosynthesis and secretion

@ast

MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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MAFA controls genes implicated in insulin biosynthesis and secretion

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P2093

A J Sharma

http://www.w3.org/2001/XMLSchema#string

C B Wollheim

http://www.w3.org/2001/XMLSchema#string

H Wang

http://www.w3.org/2001/XMLSchema#string

K Kataoka

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T Brun

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P2860

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

GLUT2 in pancreatic and extra-pancreatic gluco-detection (review).

Transcriptional activation by tetracyclines in mammalian cells

Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

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