MAFA controls genes implicated in insulin biosynthesis and secretion
about
Structure, mechanism and regulation of pyruvate carboxylaseFoxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionGeneration of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cellsCurrent status of regeneration of pancreatic β-cellsPax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretionAltered MENIN expression disrupts the MAFA differentiation pathway in insulinomaPancreatic beta cells require NeuroD to achieve and maintain functional maturityLiver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cellsLuteolin prevents uric acid-induced pancreatic β-cell dysfunction.Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphologyIslet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cellsIn vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivoA small molecule differentiation inducer increases insulin production by pancreatic β cellsMafA and MafB regulate genes critical to beta-cells in a unique temporal mannerDeconstructing pancreas developmental biology.Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and DifferentiationAccelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse.Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.Glucagon-like peptide-1 triggers protective pathways in pancreatic beta-cells exposed to glycated serum.Update on the protective molecular pathways improving pancreatic beta-cell dysfunctionGlucolipotoxicity: fuel excess and beta-cell dysfunction.The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cellsPreventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress.Detection of expressional changes induced by intrauterine growth restriction in the developing rat pancreas.Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinasep38 MAPK is a major regulator of MafA protein stability under oxidative stress.Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.
P2860
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P2860
MAFA controls genes implicated in insulin biosynthesis and secretion
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
MAFA controls genes implicated in insulin biosynthesis and secretion
@ast
MAFA controls genes implicated in insulin biosynthesis and secretion
@en
MAFA controls genes implicated in insulin biosynthesis and secretion
@nl
type
label
MAFA controls genes implicated in insulin biosynthesis and secretion
@ast
MAFA controls genes implicated in insulin biosynthesis and secretion
@en
MAFA controls genes implicated in insulin biosynthesis and secretion
@nl
prefLabel
MAFA controls genes implicated in insulin biosynthesis and secretion
@ast
MAFA controls genes implicated in insulin biosynthesis and secretion
@en
MAFA controls genes implicated in insulin biosynthesis and secretion
@nl
P2093
P2860
P1433
P1476
MAFA controls genes implicated in insulin biosynthesis and secretion
@en
P2093
P2860
P2888
P304
P356
10.1007/S00125-006-0490-2
P577
2006-12-06T00:00:00Z
P5875
P6179
1005061023