Rheb1 is required for mTORC1 and myelination in postnatal brain development - Test2 - elhamkhani - TriplyDB

Rheb1 is required for mTORC1 and myelination in postnatal brain development

Rheb1 is required for mTORC1 and myelination in postnatal brain development

http://www.wikidata.org/entity/Q34665970

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Regulation of TOR by small GTPases Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function Regulation of mTORC1 by PI3K signaling Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.mTOR signaling in tumorigenesis Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process Cardiac ablation of Rheb1 reduces sodium currents in infant mice Terahertz Spectroscopic Diagnosis of Myelin Deficit Brain in Mice and Rhesus Monkey with Chemometric Techniques.Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation.Recent progress in the study of the Rheb family GTPases.Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling.Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development.mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice.Identification of Tmem10 as a novel late-stage oligodendrocytes marker for detecting hypomyelination.Genetic deletion of Rheb1 in the brain reduces food intake and causes hypoglycemia with altered peripheral metabolism The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting.The small GTPase Rheb is required for spermatogenesis but not oogenesis.T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.Signaling mechanisms regulating myelination in the central nervous system.Akt/mTOR signalling in myelination.In vivo functions of small GTPases in neocortical development.Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.Rheb GTPase regulates β-secretase levels and amyloid β generation mTOR in Brain Physiology and Pathologies.Regulation of the proteome by amino acids.Intracellular signaling pathway regulation of myelination and remyelination in the CNS.Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes.Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus.Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.RHEB1 expression in embryonic and postnatal mouse.

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P2860

Rheb1 is required for mTORC1 and myelination in postnatal brain development

http://www.wikidata.org/entity/Q34665970

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@ast

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@en

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@nl

type

label

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@ast

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@en

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@nl

prefLabel

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@ast

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@en

Rheb1 is required for mTORC1 and myelination in postnatal brain development

@nl

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J.DEVCEL.2010.11.020

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Developmental Cell

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Rheb1 is required for mTORC1 and myelination in postnatal brain development

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Bo Xiao

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Jia Xu

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Jia Zou

http://www.w3.org/2001/XMLSchema#string

Junlong Tian

http://www.w3.org/2001/XMLSchema#string

Liang Zhou

http://www.w3.org/2001/XMLSchema#string

Maowen Luo

http://www.w3.org/2001/XMLSchema#string

Paul F Worley

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Po Yu Chen

http://www.w3.org/2001/XMLSchema#string

Qiaona Yang

http://www.w3.org/2001/XMLSchema#string

Shouyang Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

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97-108

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10.1016/J.DEVCEL.2010.11.020

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1

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49759279

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21238928

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3056331

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