Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
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Dopamine release in the basal gangliaRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Synaptic vesicle trafficking and Parkinson's diseaseLRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoAlpha-synuclein promotes SNARE-complex assembly in vivo and in vitroMembrane curvature induction and tubulation are common features of synucleins and apolipoproteins.Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Versatile Structures of α-SynucleinDynamic structural flexibility of α-synucleinAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseaseNeuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathwaysDisease-modifying therapeutic directions for Lewy-Body dementiasIs Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease?LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseIntrabodies as neuroprotective therapeuticsFunction and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescenceSynaptic dysfunction and septin protein family members in neurodegenerative diseasesSynucleins antagonize endoplasmic reticulum function to modulate dopamine transporter traffickingBehavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectorsA53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old miceDynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceThe Synaptic Function of α-SynucleinMembrane remodeling and mechanics: Experiments and simulations of α-SynucleinGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceAlpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical ApplicationThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseReducing synuclein accumulation improves neuronal survival after spinal cord injuryMutation in the SYNJ1 gene associated with autosomal recessive, early-onset ParkinsonismNeurodegenerative disease and adult neurogenesisDopamine and paraquat enhance α-synuclein-induced alterations in membrane conductanceA system for performing high throughput assays of synaptic functionαβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunctionTargeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's diseaseAlpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosisDeficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult miceTotal α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.
P2860
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P2860
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Increased expression of alpha- ...... eclustering after endocytosis.
@ast
Increased expression of alpha- ...... eclustering after endocytosis.
@en
type
label
Increased expression of alpha- ...... eclustering after endocytosis.
@ast
Increased expression of alpha- ...... eclustering after endocytosis.
@en
prefLabel
Increased expression of alpha- ...... eclustering after endocytosis.
@ast
Increased expression of alpha- ...... eclustering after endocytosis.
@en
P2093
P2860
P50
P1433
P1476
Increased expression of alpha- ...... eclustering after endocytosis.
@en
P2093
Bibiana Onoa
Farrukh A Chaudhry
Ken Nakamura
Robert H Edwards
Roger A Nicoll
Victoria Berge
P2860
P356
10.1016/J.NEURON.2009.12.023
P407
P577
2010-01-01T00:00:00Z