Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
about
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implicationsNephron-specific deletion of the prorenin receptor causes a urine concentration defect.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionCharacterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Cell-specific regulation of L-WNK1 by dietary K.Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic HypertensionGeneration and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyHypertension: the missing WNKs.Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.Multistep regulation of autophagy by WNK1WNK signalling pathways in blood pressure regulationRevisiting the NaCl cotransporter regulation by with-no-lysine kinases.Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.PPARγ Regulation in Hypertension and Metabolic Syndrome.Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population.ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.Physiological role of SLC12 family members in the kidney.Paracellular transport in the collecting duct.Ubiquitination and the Regulation of Membrane Proteins.Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3.SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.Mutant Cullin causes cardiovascular compromise.Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport.Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.Potassium Sensing by Renal Distal Tubules Requires Kir4.1.WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats.The evolving field of salt transport regulation in the Steve Hebert Lecture.Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension.Mechanisms and controversies in mutant Cul3-mediated Familial Hyperkalemic Hypertension.A novel mutation in exon 9 of Cullin 3 gene contributes to aberrant splicing in pseudohypoaldosteronism type II.WNK pathways in cancer signaling networks
P2860
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P2860
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@ast
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@en
type
label
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@ast
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@en
prefLabel
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@ast
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@en
P2093
P2860
P50
P356
P1476
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
@en
P2093
Aljona Borschewski
Belinda McCully
Bethzaida Yarbrough
Brittney Davidge
Chao-Ling Yang
Chong Zhang
Eduardo R Argaiz
Hae J Park
James A McCormick
Jeffrey D Singer
P2860
P304
P356
10.1172/JCI76126
P407
P577
2014-09-24T00:00:00Z