Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
about
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionIdentification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assayInhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Biochemical assays for the discovery of TDP1 inhibitorsDevelopment of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Synthesis, labeling and bioanalytical applications of a tris(2,2'-bipyridyl)ruthenium(II)-based electrochemiluminescence probe.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsSynthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assaySynthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapyTDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human TelomeraseBenchmarking ligand-based virtual High-Throughput Screening with the PubChem database.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Studying TDP1 Function in DNA Repair.Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
P2860
Q24294083-F9B0B80D-BF14-42BA-8445-EC615F1570B4Q24644674-76EBB1FB-1A67-41ED-8350-6E4F7178EB34Q28260713-E5D50DEF-178B-4661-B2E5-BBB3643C9895Q29400901-A49D8DD1-F658-4D6D-ADB7-9F0D7C2C9B1FQ33399360-D00F2FB0-3A66-4D4A-B686-81F8FE81FE68Q33517282-477ED866-0A05-4FBD-BA41-C9AC559279FFQ33662415-D6527198-4798-4C1B-AC95-D46CDCB6AF86Q33783186-1EF399D9-EB41-4DDB-97CF-B5DFC5889D96Q33875792-7410466C-2540-4A8A-95C0-433CAC6CF41AQ34021070-56CA3F46-6AE1-497C-A91F-C865209D7660Q35122653-0CA045DB-AA6B-4EE6-807D-64D16233C0D3Q35151845-7079A993-D0D6-4431-BDC1-0DF0F4E64099Q35167579-F2F8ED2A-A8A2-4C3D-BAEA-8ECDC3FCE976Q35954578-78DC3DEF-ACE9-432F-B035-E5F382E31CBEQ36275846-3E4E0986-EA97-4553-A07E-C729FADEE005Q36524994-36DDE3D2-A179-43C9-827E-7BBE96F57A2DQ36697144-B249DD08-1916-4ED7-A31E-7EE95759564FQ36744910-47E91156-DD69-4F87-8A9B-36E82B196B15Q37148469-9AF5A319-F5DE-4F45-8831-BF351A9704A1Q37445367-A5DF735D-A75D-48AB-9B26-FA4A01E13692Q37697354-875F30A8-AA5B-4D61-99F6-29A14657AFC8Q38261264-8BDD2584-C324-4A35-80D8-59A86D23E52BQ38608688-99FCA09B-1949-4334-A505-0B33DC103E16Q41116917-D099DC75-38A4-4372-AAE5-07F883726FAEQ41630512-9F92A26D-798E-46FA-B49F-EB4C04AE9E7AQ42107368-C22E8662-1DAB-44EF-98A2-EEC64E21A7E3Q46431649-493785A1-4345-401A-9657-9A8808B9CCDFQ47362333-2CA5DB08-1E51-4A45-AE9F-4FBC115B3A81Q56531047-E334B5A8-C60E-4EE3-A449-FC664B738B31Q58759037-6DC5F17A-3178-4696-BBA0-45D179594D3B
P2860
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@ast
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en-gb
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@nl
type
label
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@ast
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en-gb
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@nl
prefLabel
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@ast
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en-gb
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@nl
P2093
P2860
P356
P1476
Novel high-throughput electroc ...... 05831) as an inhibitor of Tdp1
@en
P2093
Andrew G Stephen
Christophe Marchand
Keli K Agama
Laurent Thibaut
Robert J Fisher
Smitha Antony
P2860
P304
P356
10.1093/NAR/GKM463
P407
P50
P577
2007-01-01T00:00:00Z