Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
about
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancerDrugging topoisomerases: lessons and challengesStructure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamilyStructural basis for recognition of 5′-phosphotyrosine adducts by Tdp2Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyTyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damageTDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and IIDesign and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Repair of DNA-polypeptide crosslinks by human excision nuclease.Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.Structure of acid deoxyribonuclease.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsHuman Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes.Neurological disorders associated with DNA strand-break processing enzymes.Recognition and repair of chemically heterogeneous structures at DNA endsEffects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsTyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavagePhospholipase D: enzymology, functionality, and chemical modulationThe hairpin ribozyme.A structural basis for allosteric control of DNA recombination by lambda integrase.Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thalianaSynthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.Repair of topoisomerase I-mediated DNA damage.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapyTDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors.Vanadate-based transition-state analog inhibitors of Cre-LoxP recombination
P2860
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P2860
Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of a transit ...... opoisomerase I-derived peptide
@ast
Crystal structure of a transit ...... opoisomerase I-derived peptide
@en
Crystal structure of a transit ...... opoisomerase I-derived peptide
@nl
type
label
Crystal structure of a transit ...... opoisomerase I-derived peptide
@ast
Crystal structure of a transit ...... opoisomerase I-derived peptide
@en
Crystal structure of a transit ...... opoisomerase I-derived peptide
@nl
prefLabel
Crystal structure of a transit ...... opoisomerase I-derived peptide
@ast
Crystal structure of a transit ...... opoisomerase I-derived peptide
@en
Crystal structure of a transit ...... opoisomerase I-derived peptide
@nl
P2093
P1476
Crystal structure of a transit ...... opoisomerase I-derived peptide
@en
P2093
Douglas R Davies
Heidrun Interthal
James J Champoux
Wim G J Hol
P304
P356
10.1016/S1074-5521(03)00021-8
P407
P577
2003-02-01T00:00:00Z