RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex
about
Insights into APC/C: from cellular function to diseases and therapeuticsE2 enzymes: more than just middle menCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationMolecular basis of APC/C regulation by the spindle assembly checkpoint.Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylationMultiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.Mechanism of APC/CCDC20 activation by mitotic phosphorylation.WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.Structural disorder and its role in proteasomal degradation.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.Specificity and disease in the ubiquitin systemThe increasing complexity of the ubiquitin code.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Detection and Analysis of Cell Cycle-Associated APC/C-Mediated Cellular Ubiquitylation In Vitro and In Vivo.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.Sumoylation promotes optimal APC/C Activation and Timely Anaphase.
P2860
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P2860
RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@ast
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@en
type
label
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@ast
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@en
prefLabel
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@ast
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@en
P2093
P2860
P50
P356
P1476
RING E3 mechanism for ubiquiti ...... man anaphase-promoting complex
@en
P2093
Christy R R Grace
Edmond R Watson
Holger Stark
Jan-Michael Peters
Jeremiah J Frye
Marcelo L Actis
Naoaki Fujii
Patrick Rodrigues
Prakash Dube
Renping Qiao
P2860
P304
P356
10.1073/PNAS.1504161112
P407
P577
2015-03-30T00:00:00Z