Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates
about
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexAllosteric regulation of E2:E3 interactions promote a processive ubiquitination machineTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesHECT and RING finger families of E3 ubiquitin ligases at a glanceE2 enzymes: more than just middle menBuilding and remodelling Cullin-RING E3 ubiquitin ligasesA Dual E3 Mechanism for Rub1 Ligation to Cdc53Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase DomainStructure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding SurfaceMechanism of ubiquitylation by dimeric RING ligase RNF4Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complexSelective Recruitment of an E2 Ubiquitin Complex by an E3 Ubiquitin LigaseMechanism of ubiquitin ligation and lysine prioritization by a HECT E3A Compact Viral Processing Proteinase/Ubiquitin Hydrolase from the OTU FamilyE2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitinStructural Diversity in the Type IV Pili of Multidrug-resistant AcinetobacterTwo Distinct Types of E3 Ligases Work in Unison to Regulate Substrate UbiquitylationStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsE2s: structurally economical and functionally repleteDimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chainsEssential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrateThe N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathwaysThe human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination.Comprehensively surveying structure and function of RING domains from Drosophila melanogasterTargeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylationTwists and turns in ubiquitin-like protein conjugation cascades.Designing photoswitchable peptides using the AsLOV2 domainInositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell deathgp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domainsDifferential gradients of interaction affinities drive efficient targeting and recycling in the GET pathwayCharacterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometryUbiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.Structural regulation of cullin-RING ubiquitin ligase complexes.A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteinsRING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex
P2860
Q24299638-D6901439-19FD-44D3-8692-9433CC918164Q24315785-43210C75-A1F2-4FE1-9A18-78E410E7BA19Q24317405-06072DDA-3A8D-49E6-8291-4621A398737AQ24337489-A30EE199-69B5-4EA2-9927-6911362A9593Q24599672-4AB034D0-73DF-433A-8DD0-6AEF8E2DD340Q26752818-6E4EA167-25F2-4486-9017-95F8F68A17E3Q27027816-BAC867E5-66DB-4A22-BE72-6F25EE2330B9Q27664416-CC87FC7F-53B2-4E83-8EB6-907CC845ED37Q27665853-24BDB5F5-275E-47DC-9AB0-53B47F4B8F1FQ27670574-2D3FB4F5-50C2-4278-A18D-4DEB302E1524Q27671855-35479D32-5D03-409E-B967-1F7ED91FA29BQ27675586-215CE374-982F-4574-9E25-B6E6D4D347B9Q27678117-5445836B-9A82-4BC8-AEB3-F600585F6CB6Q27679532-77B3DBFE-91E0-4E94-AE57-25688212612FQ27679781-DE957C6C-C40D-4EEF-A3BB-575057DB5AC6Q27680817-295430C1-30E4-4560-B094-064C2D785A8EQ27728070-234DA26E-C97E-48FE-8075-DF405BE82C03Q28115944-0BDEC41C-1673-4955-81FD-14DA5A4D2006Q28116245-4701E36A-C334-4370-86D0-C3B56383D7B8Q28301074-654F62D7-754E-4F80-AB80-4E609947E672Q28594243-DC8E9882-B448-4AE3-B5FC-971485AAB75BQ28740322-40690D81-A7C9-466D-83A6-9F5233EDF303Q30156839-F1255C7E-E94C-42A3-8759-ADB5D25D622BQ33716987-4C1EB66D-5F2A-4ECB-88DE-96DA7C7588C4Q33885264-29EE9BE4-B09B-40D9-B37F-EC0F9CEB20D6Q34017765-0FE2665D-DB1B-4FAA-8406-A7A285FA8A61Q34043797-D4B7F275-16B6-4B18-A8C6-7AB3F4CFCFEDQ34170749-E1BA17A6-9654-4B5D-AB71-BA481B6DC703Q34225698-ED5A6696-13CB-456A-9CE1-9EDC7590556CQ34269806-9E5CA71E-A5B8-495E-9C9E-E9AAA28BBA02Q34526364-532F4764-6FFE-4098-A0A1-6177C589C742Q34545649-9D24640A-C5AE-43E2-9FB6-003A4B83FC60Q34581057-BC7A1F03-86D5-4E0A-8D2C-143383E8FA03Q34670308-F59C2AE7-85CC-4741-B8B5-DE6E348F808BQ34958467-16C6AD5F-3F94-497B-A94E-D09C397C3C9BQ34994359-EF144D87-902E-4849-8B8B-4D483B209059Q35002923-9673E69D-19D5-4354-8672-19C58F314886Q35151712-3DE6F00C-F2A2-4984-BD5A-030720A4A27DQ35152082-4B2D7C22-CF05-4F34-B57E-174D8BE19CB2Q35567086-EC46ACC0-D0AD-42C2-B5A3-FAD1E63F0CB8
P2860
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@ast
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en-gb
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@nl
type
label
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@ast
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en-gb
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@nl
prefLabel
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@ast
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en-gb
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@nl
P2093
P2860
P3181
P1433
P1476
Rapid E2-E3 assembly and disas ...... NG ubiquitin ligase substrates
@en
P2093
Anjanabha Saha
Gary Kleiger
Raymond J Deshaies
Steven Lewis
P2860
P304
P3181
P356
10.1016/J.CELL.2009.10.030
P407
P577
2009-11-25T00:00:00Z