GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. - Test2 - elhamkhani - TriplyDB

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.

http://www.wikidata.org/entity/Q35762090

about

Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.Geranylgeranyl diphosphate synthase: an emerging therapeutic target Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I Targeting protein lipidation in disease Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors Targeting protein prenylation for cancer therapy Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.A novel approach to tag and identify geranylgeranylated proteins.Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells.Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 Modelling oncogenic Ras/Raf signalling in the mouse.Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice.Geranylgeranyltransferase I as a target for anti-cancer drugs Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection.Control of the innate immune response by the mevalonate pathway.Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs.Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation.The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion.Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.Differential effects of prenylation and s-acylation on type I and II ROPS membrane interaction and function.Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation.

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P2860

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.

http://www.wikidata.org/entity/Q35762090

description

2007 nî lūn-bûn

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2007年论文

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2007年论文

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name

GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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Journal of Clinical Investigation

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GGTase-I deficiency reduces tu ...... ith K-RAS-induced lung cancer.

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Andrej Tarkowski

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Anna-Karin M Sjogren

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Annika M Wahlstrom

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Birgitta Swolin

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Briony A Cutts

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Carolyn Weinbaum

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Christin Karlsson

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Karin M E Andersson

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Martin Dalin

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Martin O Bergo

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P2860

Post-translational modifications of p21rho proteins

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

KSR, a novel protein kinase required for RAS signal transduction

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Genomic analysis of metastasis reveals an essential role for RhoC

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models

Inhibitors of protein: geranylgeranyl transferases

Protein prenyltransferases

Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

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1294-1304

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10.1172/JCI30868

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5

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117

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2007-05-01T00:00:00Z

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1857236

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