Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. - Test2 - elhamkhani - TriplyDB

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

http://www.wikidata.org/entity/Q35835383

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Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection Drugging the Cancers Addicted to DNA Repair.Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex.Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells Regulation of Single-Strand Annealing and its Role in Genome Maintenance.Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair.Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics.Drugging DNA repair to target T-ALL cells.How RNA transcripts coordinate DNA recombination and repair.Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein-Nucleic Acid Interactions.

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Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

http://www.wikidata.org/entity/Q35835383

description

2015 nî lūn-bûn

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Small-Molecule Disruption of R ...... ine in BRCA-Deficient Cancers.

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Chemistry and Biology

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Small-Molecule Disruption of R ...... cine in BRCA-Deficient Cancers

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Antonio Luz

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Gurushankar Chandramouly

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J Fraser Glickman

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Katherine Sullivan

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Mark Andrake

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Richard T Pomerantz

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Tomasz Skorski

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P2860

Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing

Structure of the single-strand annealing domain of human RAD52 protein

Homologous recombination in DNA repair and DNA damage tolerance

The roles of PARP1 in gene control and cell differentiation

Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis

Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form

Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

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