β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
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Amyloidosis in Retinal Neurodegenerative DiseasesBeta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)The normal and pathologic roles of the Alzheimer's β-secretase, BACE1Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsBACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and ratsPhysiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortexFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseTargeting the β secretase BACE1 for Alzheimer's disease therapy.Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMDFuture Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapyMechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease.Developing therapeutic antibodies for neurodegenerative disease.Advances in the identification of β-secretase inhibitors.Targeting ubiquilin-1 in Alzheimer's disease.BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind.One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina.Upregulation of SET expression by BACE1 and its implications in Down syndrome.The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers.Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration.Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1.
P2860
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P2860
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@ast
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@en
type
label
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@ast
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@en
prefLabel
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@ast
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@en
P2093
P2860
P356
P1476
β-Secretase (BACE1) inhibition ...... d accumulation of age pigment.
@en
P2093
Alonso Emilio
Antonia M Joussen
Bart de Strooper
Catherine Bowes Rickman
Lutgarde Serneels
Maria B Grant
Michael E Boulton
Norbert Kociok
P2860
P304
P356
10.1002/EMMM.201101084
P577
2012-08-20T00:00:00Z