BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
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Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsOne for All? Hitting Multiple Alzheimer's Disease Targets with One DrugG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsPresumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiencyProteomic Substrate Identification for Membrane Proteases in the Brain3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish"The multiple faces of RAGE--opportunities for therapeutic intervention in aging and chronic diseaseBACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and ratsPhysiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo.Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease.BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGREffects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesEffects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: a preliminary anti- Alzheimer's studypH-Dependent Population Shift Regulates BACE1 Activity and Inhibition.Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells.BACE1 RNAi Restores the Composition of Phosphatidylethanolamine-Derivates Related to Memory Improvement in Aged 3xTg-AD Mice.Protective alleles and modifier variants in human health and disease.Filling the void: a role for exercise induced BDNF and brain amyloid precursor protein processing.Beyond immunotherapy: new approaches for disease modifying treatments for early Alzheimer's disease.Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Emerging drugs to reduce abnormal β-amyloid protein in Alzheimer's disease patients.Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.The road to restoring neural circuits for the treatment of Alzheimer's disease.Therapeutic Potentials of Microalgae in the Treatment of Alzheimer's Disease.Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid.2,2,2-Trifluoroethyl-thiadiazines: a patent evaluation of WO2016023927.Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants.Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases.Orchestration of dynamic copper navigation - new and missing pieces.Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice.A Novel Small Molecule Modulator of Amyloid Pathology.Gene Therapy in the Nervous System: Failures and Successes.Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination.
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BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
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name
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
@en
type
label
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
@en
prefLabel
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
@en
P2860
P1476
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
@en
P2093
Robert Vassar
P2860
P2888
P356
10.1186/S13195-014-0089-7
P407
P577
2014-12-24T00:00:00Z
P5875
P6179
1049425721