Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. - Test2 - elhamkhani - TriplyDB

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

http://www.wikidata.org/entity/Q33862796

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Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency Proteomic Substrate Identification for Membrane Proteases in the Brain Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 APP as a Protective Factor in Acute Neuronal Insults.Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials.Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid.Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Influence of the Melissa officinalis Leaf Extract on Long-Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action.NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.MicroRNA-135b has a neuroprotective role via targeting of β-site APP-cleaving enzyme 1.The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.Immunotherapy for Alzheimer's disease: past, present and future

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P2860

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

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2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014年の論文

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Function, therapeutic potentia ...... t status and future prospects.

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Matthew E Kennedy

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Philip C Wong

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Robert Vassar

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P2860

A missense mutation in PMEL17 is associated with the Silver coat color in the horse

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Batten's disease: clues to neuronal protein catabolism in lysosomes

Expression analysis of BACE2 in brain and peripheral tissues

BACE2 functions as an alternative alpha-secretase in cells

Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.

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