about
Statins for the prevention of dementiaStatins for the treatment of dementiaStatins for the treatment of dementiaStatins for the prevention of dementiaSorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processingApolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapyLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseSignaling effect of amyloid-beta(42) on the processing of AbetaPPElusive roles for reactive astrocytes in neurodegenerative diseasesApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer diseaseβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseProteolytic processing of Alzheimer's β-amyloid precursor proteinDeletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence.A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaNetwork Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the DiseaseNeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's diseaseOverexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearancerSeqDiff: detecting differential isoform expression from RNA-Seq data using hierarchical likelihood ratio test.1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease MiceIdentification of beta-secretase (BACE1) substrates using quantitative proteomics.Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosisPhospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD miceCentral angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.Protective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway.Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice.Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.Design, synthesis, and biological evaluation of novel fluorinated ethanolamines.Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.Cochrane review on 'Statins for the treatment of dementia'.Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.Amyloid-beta: a crucial factor in Alzheimer's disease.A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic miceMore than cholesterol transporters: lipoprotein receptors in CNS function and neurodegenerationStriking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinDifferential regulation of BACE1 expression by oxidative and nitrosative signalsLoss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The Alzheimer's disease beta-secretase enzyme, BACE1.
@ast
The Alzheimer's disease beta-secretase enzyme, BACE1.
@en
type
label
The Alzheimer's disease beta-secretase enzyme, BACE1.
@ast
The Alzheimer's disease beta-secretase enzyme, BACE1.
@en
prefLabel
The Alzheimer's disease beta-secretase enzyme, BACE1.
@ast
The Alzheimer's disease beta-secretase enzyme, BACE1.
@en
P2860
P356
P1476
The Alzheimer's disease beta-secretase enzyme, BACE1.
@en
P2093
Robert Vassar
Sarah L Cole
P2860
P2888
P356
10.1186/1750-1326-2-22
P577
2007-11-15T00:00:00Z
P5875
P6179
1031678023