Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors. - Test2 - elhamkhani - TriplyDB

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

http://www.wikidata.org/entity/Q36900522

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092 Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.SGK1: The Dark Side of PI3K Signaling.Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways Expression of serum- and glucocorticoid-regulated kinase 1 and its association with clinicopathological factors and the survival of patients with adenocarcinoma of the esophagogastric junction.Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1.mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.Targeting serum glucocorticoid-regulated kinase-1 in squamous cell carcinoma of the head and neck: a novel modality of local control Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability.Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts.SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation.AKT-independent PI3-K signaling in cancer - emerging role for SGK3.Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.Targeting PI3K/Akt/mTOR Signaling in Cancer.Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases Oncogenic MNK signalling regulates the metastasis suppressor NDRG1 Ras-ling with new therapeutic targets for metastasis.PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.mTORC1 and mTORC2 in cancer and the tumor microenvironment.The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.PI3K signaling in cancer: beyond AKT.AKT/PKB Signaling: Navigating the Network.Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells.Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas.The emerging role of serum/glucocorticoid-regulated kinases in cancer.

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P2860

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

http://www.wikidata.org/entity/Q36900522

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2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

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type

label

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

@en

prefLabel

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

@en

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Biochemical Journal

P1476

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

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P2093

Barry R Davies

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Darren Cross

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Eeva M Sommer

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Hannah Dry

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Sylvie Guichard

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P2860

Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Cap43, a novel gene specifically induced by Ni2+ compounds

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

AKT/PKB signaling: navigating downstream

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499-508

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10.1042/BJ20130342

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3

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452

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236197727

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23581296

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3671793

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