Population genetics of rare variants and complex diseases.
about
Understanding rare and common diseases in the context of human evolutionGenome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease.HapFABIA: identification of very short segments of identity by descent characterized by rare variants in large sequencing data.Robust forward simulations of recurrent hitchhikingHigh-resolution network biology: connecting sequence with function.The impact of population demography and selection on the genetic architecture of complex traits.Detection of human adaptation during the past 2000 yearsPopulation genetic simulations of complex phenotypes with implications for rare variant association testsGenetic simulation tools for post-genome wide association studies of complex diseasesInsights from GWAS: emerging landscape of mechanisms underlying complex trait diseaseFunctional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript.A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.Estimating the mutation load in human genomesPopulation growth inflates the per-individual number of deleterious mutations and reduces their mean effect.CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease.What can genome-wide association studies tell us about the evolutionary forces maintaining genetic variation for quantitative traits?A framework for how environment contributes to cancer risk.Characteristics of neutral and deleterious protein-coding variation among individuals and populations.FIRE: functional inference of genetic variants that regulate gene expression.Some surprising twists on the road to discovering the contribution of rare variants to complex diseases.RAiSD detects positive selection based on multiple signatures of a selective sweep and SNP vectors
P2860
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P2860
Population genetics of rare variants and complex diseases.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Population genetics of rare variants and complex diseases.
@en
type
label
Population genetics of rare variants and complex diseases.
@en
prefLabel
Population genetics of rare variants and complex diseases.
@en
P2093
P2860
P356
P1433
P1476
Population genetics of rare variants and complex diseases.
@en
P2093
Dara G Torgerson
M Cyrus Maher
Ryan D Hernandez
P2860
P304
P356
10.1159/000346826
P577
2012-01-01T00:00:00Z