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TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8When ubiquitin meets NF-κB: a trove for anti-cancer drug developmentON/OFF and beyond--a boolean model of apoptosisXIAP is not required for human tumor cell survival in the absence of an exogenous death signalSignaling to NF-kappaB: regulation by ubiquitination.Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitroNF-kappaB is involved in SHetA2 circumvention of TNF-alpha resistance, but not induction of intrinsic apoptosis.Cell deathA smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cellsEstrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner.LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.Reciprocal complementation of the tumoricidal effects of radiation and natural killer cellsDevelopment of inhibitors in the ubiquitination cascade.2A peptide-based, lentivirus-mediated anti-death receptor 5 chimeric antibody expression prevents tumor growth in nude miceThe Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.K63-linked ubiquitination in kinase activation and cancer.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions.Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL.cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosisCritical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation.Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.XIAP as a ubiquitin ligase in cellular signaling.Cell death pathways--potential therapeutic targets.Structural studies of NF-κB signaling.Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation.Staying alive: cell death in antiviral immunity.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway.Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro.Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c.RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells.Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cellsIKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells.Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Smac mimetics and TNFalpha: a dangerous liaison?
@en
Smac mimetics and TNFalpha: a dangerous liaison?
@nl
type
label
Smac mimetics and TNFalpha: a dangerous liaison?
@en
Smac mimetics and TNFalpha: a dangerous liaison?
@nl
prefLabel
Smac mimetics and TNFalpha: a dangerous liaison?
@en
Smac mimetics and TNFalpha: a dangerous liaison?
@nl
P2860
P1433
P1476
Smac mimetics and TNFalpha: a dangerous liaison?
@en
P2093
P2860
P304
P356
10.1016/J.CELL.2007.10.042
P407
P50
P577
2007-11-01T00:00:00Z