Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
about
The N-end rule pathwayMouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcriptionCytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5.Glutamine-specific N-terminal amidase, a component of the N-end rule pathwayDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeDegradation of the Saccharomyces cerevisiae mating-type regulator alpha1: genetic dissection of cis-determinants and trans-acting pathwaysNoncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development.Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeN-terminal acetylation of cellular proteins creates specific degradation signalsThe N-end rule pathway and regulation by proteolysisCrystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in LungThe Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.Misfolded proteins recognition strategies of E3 ubiquitin ligases and neurodegenerative diseases.DNA repair by reversal of DNA damage.Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Physiological functions and clinical implications of the N-end rule pathway.Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage.Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA DamageGlobal and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon.Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer.Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens.
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Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase
@en
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase.
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type
label
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase
@en
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase.
@nl
prefLabel
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase
@en
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase.
@nl
P2093
P2860
P356
P1476
Two proteolytic pathways regul ...... Mgt1 alkylguanine transferase
@en
P2093
Alexander Varshavsky
Anna Shemorry
Cheol-Sang Hwang
P2860
P304
P356
10.1073/PNAS.0812316106
P407
P577
2009-01-21T00:00:00Z