Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
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Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage responseThe Role of PTEN in Myeloid MalignanciesFocus on PTEN RegulationNuclear PI3K signaling in cell growth and tumorigenesisSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersParallel phase Ib studies of two schedules of buparlisib (BKM120) plus carboplatin and paclitaxel (q21 days or q28 days) for patients with advanced solid tumors.Sumoylation in gene regulation, human disease, and therapeutic action.Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinicPotentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patientsA Journey in Science: "Not Lost in Translation"PI3K and cancer: lessons, challenges and opportunitiesContribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.Sumoylation of Kif18A plays a role in regulating mitotic progressionRepair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.Ribosomal DNA copy number loss and sequence variation in cancerPTEN is a negative regulator of mitotic checkpoint complex during the cell cyclePathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesTargeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTENDissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era.Senescence and apoptosis: dueling or complementary cell fates?Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifiereEF2K--a new target in breast cancers with combined inactivation of p53 and PTENPoly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growthBGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteinsPTEN: Multiple Functions in Human Malignant TumorsLung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN.Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence.Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders.Membrane association of the PTEN tumor suppressor: neutron scattering and MD simulations reveal the structure of protein-membrane complexes.PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formationRoles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications.Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.Identification of c-MYC SUMOylation by mass spectrometry.Expression of ERG protein in prostate cancer: variability and biological correlates.ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cellsFine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivoThe Optimization of Soluble PTEN Expression in Escherichia coliMechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.
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Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@en
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@nl
type
label
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@en
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@nl
prefLabel
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@en
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@nl
P2093
P2860
P356
P1433
P1476
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
@en
P2093
R J O Dowling
S J Miller
T Srikumar
P2860
P304
P356
10.1126/SCIENCE.1236188
P407
P577
2013-07-01T00:00:00Z