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Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseEmerging modes of PINK1 signaling: another task for MARK2Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transportHyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's diseaseMechanisms and biology of B-cell leukemia/lymphoma 2/adenovirus E1B interacting protein 3 and Nip-like protein X.Normal and disordered reticulocyte maturation.Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injuryPink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal SurvivalCharacterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and DrosophilaGenetic analysis of PARK2 and PINK1 genes in Brazilian patients with early-onset Parkinson's diseaseMitophagy and Parkinson's disease: the PINK1-parkin link.Targeting mitochondrial dysfunction in neurodegenerative disease: Part I.Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis.Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.Molecular mechanisms and physiologic functions of mitochondrial dynamics.Molecular mechanisms of PINK1-related neurodegeneration.Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease.Regulation of Parkin E3 ubiquitin ligase activity.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Oxidative stress in genetic mouse models of Parkinson's disease.New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation.New insights on the mitochondrial proteome plasticity in Parkinson's disease.Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.Antioxidant modulation in restoring mitochondrial function in neurodegeneration.miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation.Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.Mitochondrial dynamics: functional link with apoptosis.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
PINK1 function in health and disease
@en
PINK1 function in health and disease.
@nl
type
label
PINK1 function in health and disease
@en
PINK1 function in health and disease.
@nl
prefLabel
PINK1 function in health and disease
@en
PINK1 function in health and disease.
@nl
P2860
P356
P1476
PINK1 function in health and disease
@en
P2093
Helene Plun-Favreau
P2860
P304
P356
10.1002/EMMM.200900024
P577
2009-06-01T00:00:00Z