Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
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Targeting BET bromodomains for cancer treatmentSegmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase ADrug Discovery Targeting Bromodomain-Containing Protein 4.Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsBET proteins are a key component of immunoglobulin gene expression.BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction.The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression.Cell-based protein stabilization assays for the detection of interactions between small-molecule inhibitors and BRD4.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.A Bead-Based Proximity Assay for BRD4 Ligand Discovery.Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cellsBRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine effortsFragment-Based Drug Discovery in the Bromodomain and Extra-Terminal Domain Family.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma.Epigenetic regulation of cardiac fibrosis.Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3.Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling.Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6.A theoretical insight into selectivity of inhibitors toward two domains of bromodomain-containing protein 4 using molecular dynamics simulations.Synthesis and biological evaluation of indazole-4,7-dione derivatives as novel BRD4 inhibitors.Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.Link Between ER-Stress, PPAR-Alpha Activation, and BET Inhibition in Relation to Apolipoprotein A-I Transcription in HepG2 Cells.Late metabolic precursors for selective aromatic residue labeling
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Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 04 February 2014
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Affinity map of bromodomain pr ...... small molecule inhibitor JQ1.
@en
Affinity map of bromodomain protein 4
@nl
type
label
Affinity map of bromodomain pr ...... small molecule inhibitor JQ1.
@en
Affinity map of bromodomain protein 4
@nl
prefLabel
Affinity map of bromodomain pr ...... small molecule inhibitor JQ1.
@en
Affinity map of bromodomain protein 4
@nl
P2093
P2860
P356
P1476
Affinity map of bromodomain pr ...... small molecule inhibitor JQ1.
@en
P2093
Benjamin Bader
Bernard Haendler
Dieter Moosmayer
Jessica Schulze
Marie Jung
Martin Philpott
Norbert Schmees
Uwe Eberspächer
Volker Badock
P2860
P304
P356
10.1074/JBC.M113.523019
P407
P577
2014-02-04T00:00:00Z