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Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceMeta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairmentsAutism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsClinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Emerging Link between Alzheimer's Disease and Homeostatic Synaptic PlasticityStriatal Circuits as a Common Node for Autism PathophysiologyAutism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?Behavioral phenotypes of genetic mouse models of autism.Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum DisordersEarly hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) miceAltered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behaviorGender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc DeficiencyDysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice.Genetic aspects of autism spectrum disorders: insights from animal modelsActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersShank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminalsTranslational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit LocalizationJAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.SHANK proteins: roles at the synapse and in autism spectrum disorder.Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness.CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.Molecular handoffs in nitrergic neurotransmissionInvestigation of SHANK3 in schizophrenia.The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia.Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of AutismLimited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice.An urgent need for experimental animal model of autism in drug development.Pre-clinical models of neurodevelopmental disorders: focus on the cerebellumShank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit.Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activationIntegrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations.Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality.
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description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Modeling autism by SHANK gene mutations in mice.
@en
type
label
Modeling autism by SHANK gene mutations in mice.
@en
prefLabel
Modeling autism by SHANK gene mutations in mice.
@en
P2860
P1433
P1476
Modeling autism by SHANK gene mutations in mice.
@en
P2093
Michael D Ehlers
Yong-Hui Jiang
P2860
P356
10.1016/J.NEURON.2013.03.016
P407
P577
2013-04-01T00:00:00Z