LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
about
Post-translational modifications as key regulators of TNF-induced necroptosisPoly-ubiquitination in TNFR1-mediated necroptosisUbiquitin modificationsThe ubiquitin system: a critical regulator of innate immunity and pathogen-host interactionsDeubiquitinases: Novel Therapeutic Targets in Immune Surveillance?Molecular basis for specificity of the Met1-linked polyubiquitin signalCYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune SignalingThe Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunityBiallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory diseaseThe linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.A20 restores phorbol ester-induced differentiation of THP-1 cells in the absence of nuclear factor-κB activation.SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.More to Life than NF-κB in TNFR1 SignalingRoles of Caspases in Necrotic Cell Death.The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis.Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication.CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.Linear ubiquitin chains: enzymes, mechanisms and biologyDiverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling.The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes.Necroptosis in cancer: An angel or a demon?SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC SignalingSPATA2 - Keeping the TNF signal short and sweet.SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.SPATA2: New insights into the assembly of the TNFR signaling complex.Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders.Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.OTULIN deficiency causes auto-inflammatory syndromeABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.SPATA2: more than a missing link.Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases.CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing.
P2860
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P2860
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
LUBAC-Recruited CYLD and A20 R ...... quitin in Signaling Complexes.
@en
type
label
LUBAC-Recruited CYLD and A20 R ...... quitin in Signaling Complexes.
@en
prefLabel
LUBAC-Recruited CYLD and A20 R ...... quitin in Signaling Complexes.
@en
P2093
P2860
P50
P1433
P1476
LUBAC-Recruited CYLD and A20 R ...... quitin in Signaling Complexes.
@en
P2093
Diego de Miguel
Eva Rieser
Helena Draberova
Henning Walczak
Lisanne Spilgies
Lucia Taraborrelli
Matthias Reichert
Sebastian Kupka
Silvia Surinova
Torsten Hartwig
P2860
P304
P356
10.1016/J.CELREP.2015.11.009
P577
2015-12-06T00:00:00Z