Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
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P1343
Mitochondria, cholesterol and cancer cell metabolismStrategically targeting MYC in cancerOncogenes strike a balance between cellular growth and homeostasisTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesAMPK as a potential anticancer target - friend or foe?AMP-activated protein kinase: a target for drugs both ancient and modernSynthetic lethal screens as a means to understand and treat MYC-driven cancersFolliculin regulates ampk-dependent autophagy and metabolic stress survivalChromodomain Helicase/ATPase DNA-Binding Protein 1-Like Gene (CHD1L) Expression and Implications for Invasion and Metastasis of Breast CancerDissecting the Dual Role of AMPK in Cancer: From Experimental to Human StudiesEvidence of cancer-promoting roles for AMPK and related kinasesDrug screening identifies niclosamide as an inhibitor of breast cancer stem-like cellsc-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and FunctionMetformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent BiosynthesisInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityIsoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cellsChemical metabolic inhibitors for the treatment of blood-borne cancersHigh metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.LKB1 mediates the development of conventional and innate T cells via AMP-dependent kinase autonomous pathways.LKB1 and AMPK and the cancer-metabolism link - ten years afterAMPK at the nexus of energetics and aging.Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responsesBIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.MYC is a critical target of FBXW7Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury.Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase.Strategies to Inhibit Myc and Their Clinical ApplicabilityA framework for identification of actionable cancer genome dependencies in small cell lung cancer.AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.Targeting MYC in cancer therapy: RNA processing offers new opportunities.
P2860
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P2860
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@en
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@nl
type
label
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@en
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@nl
prefLabel
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@en
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@nl
P2093
P2860
P50
P356
P1433
P1476
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
@en
P2093
Jannes Ulbrich
Judith Müller
Lars Zender
Lukas Aeberhard
Lukas Rycak
Nathiya Muthalagu
Ramona Rudalska
Roland Moll
Stefan Kempa
P2860
P2888
P304
P356
10.1038/NATURE10927
P407
P4510
P577
2012-03-28T00:00:00Z
P5875
P6179
1014818407