A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene - Test2 - elhamkhani - TriplyDB

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

http://www.wikidata.org/entity/Q24647664

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A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner Molecular biology of lung cancer: clinical implications Genomic screening with RNAi: results and challenges Identifying druggable disease-modifying gene products Putting a bit into the polo-box domain of polo-like kinase 1 Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine Predictive biomarkers in precision medicine and drug development against lung cancer Identification of aberrant pathways and network activities from high-throughput data Non-coding RNAs in lung cancer Molecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage response Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel Targeting the RAS oncogene.KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.RAS isoforms and mutations in cancer at a glance Synthetic lethality in lung cancer and translation to clinical therapies Drugging the addict: non-oncogene addiction as a target for cancer therapy Prediction of Genetic Interactions Using Machine Learning and Network Properties Genomic profiling toward precision medicine in non-small cell lung cancer: getting beyond EGFR Polo-like kinase and its inhibitors: Ready for the match to start?RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation ScreenBEAM: a novel meta-analysis algorithm for functional genomics screens via Bayesian hierarchical modeling Targeting the adaptability of heterogeneous aneuploids RNAi screening comes of age: improved techniques and complementary approaches Next-generation genomics: an integrative approach OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

http://www.wikidata.org/entity/Q24647664

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

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A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@en

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

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type

label

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@ast

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@en

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@nl

prefLabel

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@ast

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@en

A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

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J.CELL.2009.05.006

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A genome-wide RNAi screen iden ...... ractions with the Ras oncogene

@en

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Chad J Creighton

http://www.w3.org/2001/XMLSchema#string

Danan Li

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Ji Luo

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Michael J Emanuele

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Michael R Schlabach

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Thomas F Westbrook

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P2860

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells

Cancer cells and normal cells differ in their requirements for Thoc1

Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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835-48

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1164211

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10.1016/J.CELL.2009.05.006

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5

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137

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Stephen Elledge

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2009-05-29T00:00:00Z

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26261470

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19490893

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2768667

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