Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.

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http://www.wikidata.org/entity/Q39396732
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligaseThe p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humansMDM2 oligomers: antagonizers of the guardian of the genome.Limiting the power of p53 through the ubiquitin proteasome pathway.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerensDysfunction of the MDM2/p53 axis is linked to premature aging.Mdm2 in evolutionStructural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.Length matters: C-terminal tails regulate Mdm2-MdmX complexes.Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library.The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2).
P2860

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.

Item
http://www.wikidata.org/entity/Q39396732
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
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2012年学术文章
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2012年學術文章
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2012年學術文章
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Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@en
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@nl
type
label
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@en
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@nl
prefLabel
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@en
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Mutational analysis of Mdm2 C- ...... rs and Mdm2/MdmX heterodimers.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P932