Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate.
about
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerPhosphoinositides: tiny lipids with giant impact on cell regulationPIP kinases define PI4,5P₂signaling specificity by association with effectorsEvolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localizationPcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceDistribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform.SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.The emerging role of PtdIns5P: another signalling phosphoinositide takes its place.The emerging role of speckle-type POZ protein (SPOP) in cancer development.Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer.Exploring phosphatidylinositol 5-phosphate 4-kinase function.PtdIns5P: news and views of its appearance, disappearance and deeds.A novel gene expression pathway regulated by nuclear phosphoinositidesStability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteinsSPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylaseProstate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage.The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability.Nuclear phosphoinositides and their roles in cell biology and disease.Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.Differential expression of speckled POZ protein, SPOP: putative regulation by miR-145.Nuclear phosphoinositide regulation of chromatin.Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways.Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.RNA interference-mediated silencing of speckle-type POZ protein promotes apoptosis of renal cell cancer cells.CUL3 and protein kinases: insights from PLK1/KLHL22 interaction.[Phosphoinositides: lipidic essential actors in the intracellular traffic].PIPKIIα is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells.
P2860
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P2860
Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Coordinated activation of the ...... sphatidylinositol 5-phosphate.
@en
type
label
Coordinated activation of the ...... sphatidylinositol 5-phosphate.
@en
prefLabel
Coordinated activation of the ...... sphatidylinositol 5-phosphate.
@en
P2860
P356
P1476
Coordinated activation of the ...... osphatidylinositol 5-phosphate
@en
P2093
Igor V Boronenkov
Matthew W Bunce
P2860
P304
P356
10.1074/JBC.M710222200
P407
P577
2008-01-24T00:00:00Z