MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
about
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionJSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwayDirect activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosisHPK1, a hematopoietic protein kinase activating the SAPK/JNK pathwayMixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathwaysMixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipidHuman mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascadesMip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiationModulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascadeThe MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosisMixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complexSynergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationIsoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinaseA comprehensive pathway map of epidermal growth factor receptor signalingMLK3 Signaling in Cancer InvasionDifferential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinasesMixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cellsThe small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal deathRegulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.Role of Nogo-A in neuronal survival in the reperfused ischemic brainMixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cellsTranscriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesisIdentification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection.A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis.Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3.Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage.Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemiaDrosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif.
P2860
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P2860
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
@en
type
label
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
@en
prefLabel
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
@en
P2093
P2860
P1433
P1476
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
@en
P2093
J R Woodgett
L A Tibbles
N J Lassam
P2860
P304
P356
10.1002/J.1460-2075.1996.TB01094.X
P407
P577
1996-12-01T00:00:00Z