An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
about
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicingPurification and characterization of native spliceosomes suitable for three-dimensional structural analysis.Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56Prp8 protein: at the heart of the spliceosomeThe N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA bindingp68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex.A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formationMultiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangementsThe network of protein-protein interactions within the human U4/U6.U5 tri-snRNPDEAD-box proteins as RNA helicases and chaperonesNext-generation SELEX identifies sequence and structural determinants of splicing factor binding in human pre-mRNA sequenceDead-box proteins: a family affair--active and passive players in RNP-remodelingExtended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionThe organization and contribution of helicases to RNA splicingFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRNA helicases in splicingRNA helicase proteins as chaperones and remodelersStructure and function of an RNase H domain at the heart of the spliceosomeStructural and functional analysis of the human spliceosomal DEAD-box helicase Prp28Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicingAssembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing.The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.Inhibition of a spliceosome turnover pathway suppresses splicing defects.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationSplicing proofreading at 5' splice sites by ATPase Prp28p.The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex.Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.Functional and physical interactions between components of the Prp19p-associated complexA novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly.Strategies for RNA folding and assemblyCharacterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemThe 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase siteThe ATP requirement for U2 snRNP addition is linked to the pre-mRNA region 5' to the branch site.Spliceosome Structure and FunctionQuantifying the energetic interplay of RNA tertiary and secondary structure interactions.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.
P2860
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P2860
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
@en
type
label
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
@en
prefLabel
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
@en
P1433
P1476
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
@en
P2093
P356
10.1016/S1097-2765(00)80174-4
P577
1999-01-01T00:00:00Z