WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. - Test2 - elhamkhani - TriplyDB

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

http://www.wikidata.org/entity/Q42676343

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Hedgehog Signaling in the Maintenance of Cancer Stem Cells Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth.SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling Tug of war between survival and death: exploring ATM function in cancer.SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner.Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression.PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.The rationale for targeted therapies in medulloblastoma.Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality.Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability.Pathways to chromothripsis.WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma The emerging roles of phosphatases in Hedgehog pathway.Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe.Hedgehog signalling pathway inhibitors as cancer suppressing agents Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

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P2860

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

http://www.wikidata.org/entity/Q42676343

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@en

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@nl

type

label

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@en

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@nl

prefLabel

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@en

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

@nl

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WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

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J Y Penachioni

http://www.w3.org/2001/XMLSchema#string

L Borgognoni

http://www.w3.org/2001/XMLSchema#string

M C Vinci

http://www.w3.org/2001/XMLSchema#string

S Pandolfi

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V Montagnani

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P2860

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2

The crosstalk of mTOR/S6K1 and Hedgehog pathways

Activating Smoothened mutations in sporadic basal-cell carcinoma

Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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10.1038/ONC.2012.502

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40

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32

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1006878030

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23146903

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