A public-private partnership to unlock the untargeted kinome.
about
Ten things you should know about protein kinases: IUPHAR Review 14Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistanceDe Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding FragmentsAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase InhibitorsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsThe IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligandsThe Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerAllosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)Polypharmacology in Precision Oncology: Current Applications and Future ProspectsIdentification of potent Yes1 kinase inhibitors using a library screening approach.Chemical interrogation of the malaria kinome.Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.Proteomics in cancer biomarkers discovery: challenges and applications.Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets.Innovation in academic chemical screening: filling the gaps in chemical biologyChk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cellsAssessing adaptation of the cancer kinome in response to targeted therapies.Going for broke: targeting the human cancer pseudokinome.Progress toward JAK1-selective inhibitors.c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Progress towards a public chemogenomic set for protein kinases and a call for contributions.Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.Synthetic phosphorylation of p38α recapitulates protein kinase activityIntegration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species.Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.The target landscape of clinical kinase drugs.What is the future of bromodomains in targeted drug development?Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.Effect of missing data on multitask prediction methods.Immuno-detection by sequencing enables large-scale high-dimensional phenotyping in cells.Probing questions
P2860
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P2860
A public-private partnership to unlock the untargeted kinome.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
A public-private partnership to unlock the untargeted kinome.
@en
A public-private partnership to unlock the untargeted kinome.
@nl
type
label
A public-private partnership to unlock the untargeted kinome.
@en
A public-private partnership to unlock the untargeted kinome.
@nl
prefLabel
A public-private partnership to unlock the untargeted kinome.
@en
A public-private partnership to unlock the untargeted kinome.
@nl
P2093
P2860
P50
P356
P1476
A public-private partnership to unlock the untargeted kinome.
@en
P2093
Doriano Fabbro
Julian Blagg
Karen E Lackey
Nathanael S Gray
Nicholas C O Tomkinson
Paul Gillespie
Paulo Arruda
Paulo Mazzafera
Timothy M Willson
William J Zuercher
P2860
P2888
P356
10.1038/NCHEMBIO.1113
P577
2013-01-01T00:00:00Z