Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy
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Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutationsCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Structural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: a multi-site Förster resonance energy transfer studyPerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsThin filament mutations: developing an integrative approach to a complex disorderCa(2+)-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on filCa(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.Genotype-specific pathogenic effects in human dilated cardiomyopathy.Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.Effects of HCM cTnI mutation R145G on troponin structure and modulation by PKA phosphorylation elucidated by molecular dynamics simulationsMolecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin.Micromechanical thermal assays of Ca2+-regulated thin-filament function and modulation by hypertrophic cardiomyopathy mutants of human cardiac troponinInsights into restrictive cardiomyopathy from clinical and animal studies.Kinetic mechanism of the Ca2+-dependent switch-on and switch-off of cardiac troponin in myofibrils.Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin IFunctional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic miceMechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy.Role of cardiac troponin I carboxy terminal mobile domain and linker sequence in regulating cardiac contraction.Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.How do mutations in contractile proteins cause the primary familial cardiomyopathies?Inherited cardiomyopathies caused by troponin mutations.The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).Pharmacogenetics of cardiac inotropy.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I)Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.Determining pathogenicity of genetic variants in hypertrophic cardiomyopathy: importance of periodic reassessment.Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.Defective dynamic properties of human cardiac troponin mutations.Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.Myocardial contractile and metabolic properties of familial hypertrophic cardiomyopathy caused by cardiac troponin I gene mutations: a simulation study.
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P2860
Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Functional consequences of the ...... al hypertrophic cardiomyopathy
@ast
Functional consequences of the ...... al hypertrophic cardiomyopathy
@en
Functional consequences of the ...... al hypertrophic cardiomyopathy
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Functional consequences of the ...... al hypertrophic cardiomyopathy
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Functional consequences of the ...... al hypertrophic cardiomyopathy
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Functional consequences of the ...... al hypertrophic cardiomyopathy
@en
Functional consequences of the ...... al hypertrophic cardiomyopathy
@en-gb
Functional consequences of the ...... al hypertrophic cardiomyopathy
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prefLabel
Functional consequences of the ...... al hypertrophic cardiomyopathy
@ast
Functional consequences of the ...... al hypertrophic cardiomyopathy
@en
Functional consequences of the ...... al hypertrophic cardiomyopathy
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Functional consequences of the ...... al hypertrophic cardiomyopathy
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P2093
P921
P3181
P356
P1476
Functional consequences of the ...... al hypertrophic cardiomyopathy
@en
P2093
F Shiraishi
F Takahashi-Yanaga
R Minakami
S Morimoto
T Sasaguri
P304
P3181
P356
10.1006/JMCC.2001.1473
P407
P577
2001-12-01T00:00:00Z