Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.
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Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filamentsKinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculaeCa(2+)-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on filPKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.Ca2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number.Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscleInteraction between troponin and myosin enhances contractile activity of myosin in cardiac muscle.Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin.Micromechanical thermal assays of Ca2+-regulated thin-filament function and modulation by hypertrophic cardiomyopathy mutants of human cardiac troponinDetection of target ssDNA using a microfabricated Hall magnetometer with correlated optical readout.Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin CTroponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic miceSlowed Dynamics of Thin Filament Regulatory Units Reduces Ca(2+)-Sensitivity of Cardiac Biomechanical Function.Role of cardiac troponin I carboxy terminal mobile domain and linker sequence in regulating cardiac contraction.The functional significance of the last 5 residues of the C-terminus of cardiac troponin I.Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.Ala scanning of the inhibitory region of cardiac troponin I.Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Order-Disorder Transitions in the Cardiac Troponin Complex.Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I)The cardiac troponin C mutation Leu29Gln found in a patient with hypertrophic cardiomyopathy does not alter contractile parameters in skinned murine myocardium.The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.The L-type Ca(2+) channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy.Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin.Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.Defective dynamic properties of human cardiac troponin mutations.Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.Myocardial contractile and metabolic properties of familial hypertrophic cardiomyopathy caused by cardiac troponin I gene mutations: a simulation study.Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction.Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres.Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle.Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.
P2860
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P2860
Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@en
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@nl
type
label
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@en
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@nl
prefLabel
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@en
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@nl
P2093
P2860
P1476
Familial hypertrophic cardiomy ...... 06Q) enhance filament sliding.
@en
P2093
Albert M Gordon
Anthony J Rivera
Bernhard Brenner
Chien-Kao Wang
Donald A Martyn
Jan Köhler
Michael Regnier
P Bryant Chase
Theresia Kraft
P2860
P304
P356
10.1152/PHYSIOLGENOMICS.00101.2002
P577
2003-07-07T00:00:00Z