about
Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantationRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingThe neurology of mTORTen things you should know about protein kinases: IUPHAR Review 14The expanding role of mTOR in cancer cell growth and proliferationTor forms a dimer through an N-terminal helical solenoid with a complex topology.The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Architecture of human mTOR complex 1Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and LifespanThe DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosisPredicting mTOR inhibitors with a classifier using recursive partitioning and Naïve Bayesian approachesRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationProtein Crystallography from the Perspective of Technology DevelopmentsTranscriptome sequencing analysis reveals the regulation of the hypopharyngeal glands in the honey bee, Apis mellifera carnica PollmannStructures of closed and open conformations of dimeric human ATMThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationResveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.Molecular genetics of clear-cell renal cell carcinomaIn silico investigation of potential mTOR inhibitors from traditional Chinese medicine for treatment of Leigh syndromeStructural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a timeTumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapyA critical role for mTORC1 in erythropoiesis and anemia.Structure of the human dimeric ATM kinase.Growing knowledge of the mTOR signaling network.Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown.Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombeGab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestryTumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effectmTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
mTOR kinase structure, mechanism and regulation
@ast
mTOR kinase structure, mechanism and regulation
@en
mTOR kinase structure, mechanism and regulation
@nl
type
label
mTOR kinase structure, mechanism and regulation
@ast
mTOR kinase structure, mechanism and regulation
@en
mTOR kinase structure, mechanism and regulation
@nl
prefLabel
mTOR kinase structure, mechanism and regulation
@ast
mTOR kinase structure, mechanism and regulation
@en
mTOR kinase structure, mechanism and regulation
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
mTOR kinase structure, mechanism and regulation
@en
P2093
Bhamini Vaidialingam
Derek G Rudge
Haijuan Yang
Hyo J Yang
Nikola P Pavletich
P2860
P2888
P304
P3181
P356
10.1038/NATURE12122
P407
P577
2013-05-01T00:00:00Z
P5875
P6179
1019953641