Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6
about
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and functionFoxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expressionFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteExtended exenatide administration enhances lipid metabolism and exacerbates pancreatic injury in mice on a high fat, high carbohydrate dietTranscription factor regulation of pancreatic organogenesis, differentiation and maturationPax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretionTargeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region.The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cellsIslet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway.Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.GATA4 and GATA6 control mouse pancreas organogenesis.Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genesGlobal analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencingAssaying the regulatory potential of mammalian conserved non-coding sequences in human cellsThe diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation.Temporal regulation of Ath5 gene expression during eye developmentMODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsCharacterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning.MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells.Regulation of pancreas duodenum homeobox-1 expression by early growth response-1.Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription.Pleiotropic Roles of PDX-1 in the PancreasThe islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression.Identification of a novel PDX-1 binding site in the human insulin gene enhancer.Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell Development.Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.
P2860
Q24337000-8B9A25E5-5AE7-4FEB-84CA-3623DBF29D69Q24653598-DF8DC644-5FA1-44EA-8BBD-869A24C3EBE3Q24671057-9D47CBCF-7B65-482F-9FEC-51762559A7C6Q27339590-6A227D2B-E039-4963-BFA8-1E7A1F74312DQ28083955-2D953811-AD14-46FE-859B-01DB814705C2Q28572440-2B796E59-BCB0-43A5-B9D9-B9079DCA0F06Q28593881-3A1D89E6-F501-4093-BCA9-B8ED6A494794Q30441221-9B2F06FC-DAE4-445F-A6F5-751B74B5BCA2Q33342303-34411697-23AF-440B-9797-D75C1BF99408Q33637181-A3761C16-2F79-4C64-8ACB-3961FB5EAAD3Q33726511-C975E894-E175-43FB-BAE3-ECE34E7A456EQ34119780-13D23F97-3133-4906-8963-D477F35A40B7Q34657904-02F284D5-5603-44C7-9AAD-69D64BB0323AQ35796349-B651478E-10C9-408F-B963-13B59F783A67Q35854102-FE0B6388-A4DB-4870-960F-2B66C9DF71E6Q35856972-C0CCEC99-C230-4F67-BCF6-237A91615762Q36290293-178C4292-780D-41E0-9EB3-39B80DC95377Q36596140-E9F866E5-AAE4-4565-8916-94148B8D1C9FQ36824035-C79F2A53-4096-49C3-B860-5E0A8249BB45Q37105909-1719E67A-A838-45EB-9045-6E18DEE18574Q37241357-DDE8BC9B-B9D6-45DD-B7F8-259253F314BCQ37251911-F3A89A37-E34E-49A5-A96C-2A8E8F98ECDDQ37458982-009AC641-8D81-419B-A6F2-6B5D69CBD0FAQ37479390-315286FF-DC73-4919-A9D8-B767B0A61B04Q38298690-DBF8BBF0-6AF3-4AF5-A12A-2D629547435CQ38697392-E77D4E9A-0B58-4A10-9AB8-DE63040D514DQ39975757-33ACFFF2-FC46-43FD-8AD8-F4700DC3ED77Q40199807-1ECC9978-6825-41E0-BA9D-31F143391678Q40376352-ED05D6D5-D672-4EC8-BD85-940408F26C89Q40606583-031791EC-4C55-4462-B946-1065DF9F0B03Q42280966-989B6DD5-F098-46FF-88F4-0818ACE67AADQ42805946-9DEF3B6C-7856-44D8-9495-1C822B2FA06FQ42830601-86A7F5E1-A36F-4FDE-AADA-CC28076CACB8Q42856791-B90140FA-5C1C-4180-B5BB-136E907E1DB5Q44212502-6D985831-0F67-448B-B1F2-298B8234EF0BQ47614401-DDEC0F35-08F2-4166-86C5-E6261334E3DFQ53640894-D73DD2E7-B03F-409D-A448-47407DCE404E
P2860
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@ast
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en-gb
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@nl
type
label
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@ast
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en-gb
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@nl
prefLabel
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@ast
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en-gb
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@nl
P2093
P2860
P1476
Conserved sequences in a tissu ...... nuclear factor 3 beta and Pax6
@en
P2093
Christopher V E Wright
Kevin Gerrish
Maureen Gannon
Michelle A Cissell
Roland Stein
Susan E Samaras
P2860
P304
P356
10.1128/MCB.22.13.4702-4713.2002
P407
P577
2002-07-01T00:00:00Z