R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
about
Out of balance: R-loops in human diseaseThe mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayGenome instability and transcription elongation impairment in human cells depleted of THO/TREXThe RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesNew insights into repeat instability: role of RNA•DNA hybridsEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHuman activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminationsEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainMutations, kataegis and translocations in B cells: understanding AID promiscuous activityRegulation of Aicda expression and AID activityBreaking bad: R-loops and genome integrityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationIgH chain class switch recombination: mechanism and regulationActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.AID targeting is dependent on RNA polymerase II pausing.An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.Snaps and mends: DNA breaks and chromosomal translocationsRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeFlexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune systemAID targeting: old mysteries and new challengesShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationA PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complexGrowth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPFProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.AID and Apobec3G haphazard deamination and mutational diversityIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceEvolution of antibody class switching: identification and transcriptional control of an Inu exon in the duck (Anas platyrhynchos).Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Meiotic recombination hotspots of fission yeast are directed to loci that express non-coding RNA.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Mechanisms of chromosomal rearrangement in the human genomeGeneration and characterization of endonuclease G null mice.
P2860
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P2860
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@ast
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@en
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@nl
type
label
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@ast
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@en
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@nl
prefLabel
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@ast
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@en
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@nl
P2093
P356
P1433
P1476
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.
@en
P2093
Chih-Lin Hsieh
Frederic Chedin
Michael R Lieber
Thomas E Wilson
P304
P356
10.1038/NI919
P407
P577
2003-05-01T00:00:00Z