Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
about
Redox-directed cancer therapeutics: molecular mechanisms and opportunitiesMechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein InhibitionIn Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B SignalingNovel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosisRelationships between metabolic and non-metabolic susceptibility factors in benzene toxicity.Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion.P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor.Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.Antitumour indolequinones: synthesis and activity against human pancreatic cancer cellsA direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinonesHuman NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups.Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential.Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinonesA structurally conserved water molecule in Rossmann dinucleotide-binding domains.NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.Copper(II)-Mediated Synthesis of Indolequinones from Bromoquinones and Enamines.Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation.3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
P2860
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P2860
Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Characterization of a mechanis ...... mass spectrometric approaches
@ast
Characterization of a mechanis ...... mass spectrometric approaches
@en
Characterization of a mechanis ...... mass spectrometric approaches
@nl
type
label
Characterization of a mechanis ...... mass spectrometric approaches
@ast
Characterization of a mechanis ...... mass spectrometric approaches
@en
Characterization of a mechanis ...... mass spectrometric approaches
@nl
prefLabel
Characterization of a mechanis ...... mass spectrometric approaches
@ast
Characterization of a mechanis ...... mass spectrometric approaches
@en
Characterization of a mechanis ...... mass spectrometric approaches
@nl
P2093
P50
P3181
P356
P1433
P1476
Characterization of a mechanis ...... mass spectrometric approaches
@en
P2093
P304
15135-15142
P3181
P356
10.1021/BI011324I
P407
P577
2001-12-01T00:00:00Z