Energy analysis of chemistry for correct insertion by DNA polymerase beta.
about
The Closing Mechanism of DNA Polymerase I at Atomic ResolutionA new paradigm of DNA synthesis: three-metal-ion catalysis.Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA PolymeraseBidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymeraseβ,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA PolymerasesAmino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer ReactionObserving a DNA Polymerase Choose Right from WrongStructure and mechanism of DNA polymerase βTerminal deoxynucleotidyl transferase: the story of a misguided DNA polymeraseA water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV.Polymerase-tailored variations in the water-mediated and substrate-assisted mechanism for nucleotidyl transfer: insights from a study of T7 DNA polymerase.Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionKinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.Revealing the role of the product metal in DNA polymerase β catalysis.Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantEffect of oxidatively damaged DNA on the active site preorganization during nucleotide incorporation in a high fidelity polymerase from Bacillus stearothermophilus.Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2.Lee Pedersen's work in theoretical and computational chemistry and biochemistryPrechemistry versus preorganization in DNA replication fidelity.Base excision repair and design of small molecule inhibitors of human DNA polymerase β.Metal-induced DNA translocation leads to DNA polymerase conformational activation.New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis.Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.The X family portrait: structural insights into biological functions of X family polymerases.An abridged transition state model to derive structure, dynamics, and energy components of DNA polymerase β fidelity.Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta.Exploring the role of large conformational changes in the fidelity of DNA polymerase betaPerspective: pre-chemistry conformational changes in DNA polymerase mechanismsCatalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies.Computational simulation strategies for analysis of multisubunit RNA polymerases.Relationship between conformational changes in pol lambda's active site upon binding incorrect nucleotides and mismatch incorporation rates.Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment.Why nature really chose phosphate.Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.
P2860
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P2860
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@ast
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@en
type
label
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@ast
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@en
prefLabel
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@ast
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@en
P2093
P2860
P356
P1476
Energy analysis of chemistry for correct insertion by DNA polymerase beta.
@en
P2093
Lee G Pedersen
Samuel H Wilson
Vinod K Batra
William A Beard
P2860
P304
13294-13299
P356
10.1073/PNAS.0606006103
P407
P577
2006-08-28T00:00:00Z