The structural basis for the sensing and binding of cyclic di-GMP by STING
about
Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotidesAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Ubiquitin signaling in immune responsesCyclic di-GMP: the first 25 years of a universal bacterial second messengerRationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsSpecies-specific detection of the antiviral small-molecule compound CMA by STINGCyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP SynthaseStructural Insights into the Functions of TBK1 in Innate Antimicrobial ImmunityCyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STINGStructure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAACyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationInnate immune detection of microbial nucleic acids.International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseRat and human STINGs profile similarly towards anticancer/antiviral compoundsInnate immune pattern recognition: a cell biological perspectiveThe helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseNLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STINGComplex structure and biochemical characterization of the Staphylococcus aureus cyclic diadenylate monophosphate (c-di-AMP)-binding protein PstA, the founding member of a new signal transduction protein family.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGcGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme functionSTING recognition of cytoplasmic DNA instigates cellular defense.Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acidThe innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGThe mechanism of double-stranded DNA sensing through the cGAS-STING pathwaySARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.Structural biology of innate immunity.Single amino acid change in STING leads to constitutive active signaling.UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+ (RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP)Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activityDiversity of Cyclic Di-GMP-Binding Proteins and Mechanisms.Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.Binding of bacterial secondary messenger molecule c di-GMP is a STING operationLigand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1The cGAS-STING pathway for DNA sensing.Anticancer flavonoids are mouse-selective STING agonists.Cyclic dinucleotides and the innate immune response.Molecular basis of DNA recognition in the immune system.Immune sensing of DNA
P2860
Q21132463-5B1CE003-3599-4949-B9E0-A8139FB7BFA5Q24338728-58A5322E-73E4-4464-8737-28C78B243F52Q26751376-9D956328-BD4A-4718-8FDE-30806D048940Q26850396-B82B66F8-8F74-4016-8D23-2C6A1D2E6233Q27025822-3C675C6B-3006-485F-A170-0C7E8D1D6F65Q27677466-58E6BED4-9950-4795-94EF-62B2FA057106Q27678007-66918692-7879-481F-9111-972386A01654Q27678533-68E273F6-4957-47D7-B66A-CECBD79ABE07Q27678540-75778F88-5D1C-4317-84CC-AEAEB08581CBQ27679344-55DABC84-537C-4D45-B53E-C721A2C0DE89Q27680866-B0204301-2D7F-483F-9B79-A97CE38820E1Q27691461-B913A8DA-52D9-4CD3-BF1F-248F70E5DFA2Q28081406-C40A85BB-18B1-494A-BAA2-438A322EB362Q28118888-D1A86851-3B65-4284-A3FE-23D4328905B9Q28255348-6FB2247E-E1CA-469D-8DA3-4625D425A91DQ28510485-58C69DE3-57B0-4594-8FB2-01D4BED11DFAQ28975619-FCCC5F90-78FD-4012-B4CD-B3AC02F830F5Q30878082-34C43A84-FBBC-41AC-B6AD-82474314D900Q33983673-38A9AE1A-CCB1-4BD9-A92F-82E4374E43A7Q34084866-AE4D9757-CF80-4E09-9277-6444DC0FD5D1Q34199004-1E772054-D75F-45A6-B6E1-71A8BA2C40C9Q34332186-818EF29A-EDE1-46B8-9958-DB918D84990AQ34339243-A85C1C92-2CE8-40C7-9DD2-2E13FCA677DFQ34346633-DE66CE79-08F8-4825-85C8-3A8246E4A289Q34624278-388B6E97-93A9-44CE-B5C8-4215C0C77311Q35119171-28B99D4B-08CA-4651-A262-5762FF31FFD2Q35374728-728AC16F-50A3-494B-9F83-18A7B85C1BBCQ35581615-2E1A1A2A-8FF9-44B7-9F37-0784B03FE7BCQ35583137-7F0A4ADB-E25D-43C3-AB20-3404D5C7DFB0Q35783182-6A61E2C0-4191-4DCD-9D2E-B3CAA7E4AB2CQ36128779-612A4B90-E674-4032-861B-84DC644616D3Q36390608-1D836C16-C1D5-4E9B-83A2-98E1213A270FQ36447597-2AE0F46D-FF5A-4B15-849B-39EE157BA7DDQ36922906-9612D674-F17C-4434-95A8-D4F918A5758FQ37149925-25E55691-A8A4-4AD3-B456-FFCFB8514EF3Q37196072-1A2DD187-EE7C-4E67-A580-11FBA2E39974Q37273934-1468D2C7-284F-4401-8021-C644ADEA1BA5Q37597305-C47377A8-6DF9-4E7C-B4E5-36677EF0D4C1Q38082423-699F33D1-6C61-4BEF-8C2A-D6819B1B5688Q38109307-5870BECA-565E-4F76-9EDC-FD5003490B65
P2860
The structural basis for the sensing and binding of cyclic di-GMP by STING
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The structural basis for the sensing and binding of cyclic di-GMP by STING
@ast
The structural basis for the sensing and binding of cyclic di-GMP by STING
@en
The structural basis for the sensing and binding of cyclic di-GMP by STING
@nl
type
label
The structural basis for the sensing and binding of cyclic di-GMP by STING
@ast
The structural basis for the sensing and binding of cyclic di-GMP by STING
@en
The structural basis for the sensing and binding of cyclic di-GMP by STING
@nl
prefLabel
The structural basis for the sensing and binding of cyclic di-GMP by STING
@ast
The structural basis for the sensing and binding of cyclic di-GMP by STING
@en
The structural basis for the sensing and binding of cyclic di-GMP by STING
@nl
P2093
P2860
P921
P3181
P356
P1476
The structural basis for the sensing and binding of cyclic di-GMP by STING
@en
P2093
Xiang-Yu Liu
Xiao-Dong Su
Xiao-Xia Du
Yi-He Huang
Zheng-Fan Jiang
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2333
P577
2012-06-24T00:00:00Z
P5875
P6179
1015563985