Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
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NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signalingNek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlMitotic regulation by NIMA-related kinasesMAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationStructure and regulation of the human Nek2 centrosomal kinaseAminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural CharacterizationDesign of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular ActivityUncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation.Centrosome - a promising anti-cancer targetPhosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytesNever-in-mitosis related kinase 1 functions in DNA damage response and checkpoint controlSpatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.The Ndc80 complex: integrating the kinetochore's many movements.The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutantSarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer.Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Targeting tumor suppressor networks for cancer therapeutics.The Set1/COMPASS histone H3 methyltransferase helps regulate mitosis with the CDK1 and NIMA mitotic kinases in Aspergillus nidulansNek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatmentMutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityAdenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase.Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer.Structural organization of the kinetochore-microtubule interface.Giardia lamblia Nek1 and Nek2 kinases affect mitosis and excystation.The APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.Centromere cohesion: regulating the guardian.Targeting NEK2 as a promising therapeutic approach for cancer treatment.Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Mitosis as an anti-cancer drug target.Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo.
P2860
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P2860
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@ast
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@en
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@nl
type
label
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@ast
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@en
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@nl
prefLabel
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@ast
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@en
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@nl
P2093
P2860
P3181
P356
P1476
Phosphorylation of the mitotic ...... ithful chromosome segregation.
@en
P2093
Daniel J Riley
Phang-Lang Chen
Wen-Hwa Lee
Yumay Chen
P2860
P304
P3181
P356
10.1074/JBC.M207069200
P407
P577
2002-12-20T00:00:00Z