Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit
about
Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activityCaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitationCaV1.2 signaling complexes in the heartReciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channelsPhosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunitNew short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channelStimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C)Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytesCyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytesPhosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in miceAKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signalingDifferential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunitsProtein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinaseThe AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cellsThe ß subunit of voltage-gated Ca2+ channelsSer(1901) of alpha(1C) subunit is required for the PKA-mediated enhancement of L-type Ca(2+) channel currents but not for the negative shift of activation.Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failureRegulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neuronsPKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.Modulation of voltage-dependent Ba2+ currents in the guinea-pig gastric antrum by cyclic nucleotide-dependent pathways.Calcium and arrhythmogenesis.Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation.Physiological modulation of inactivation in L-type Ca2+ channels: one switch.Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts.Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channelRegulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha).Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications.Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel.Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicingBeta-adrenergic stimulation of L-type Ca2+ channels in cardiac myocytes requires the distal carboxyl terminus of alpha1C but not serine 1928Supramolecular assemblies and localized regulation of voltage-gated ion channels.Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response.Reverse engineering the L-type Ca2+ channel alpha1c subunit in adult cardiac myocytes using novel adenoviral vectorsTransgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.Oxidant sensing by protein kinases a and g enables integration of cell redox state with phosphoregulation.L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.
P2860
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P2860
Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@ast
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@en
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@nl
type
label
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@ast
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@en
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@nl
prefLabel
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@ast
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@en
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@nl
P2093
P356
P1476
Functional regulation of L-typ ...... ylation of the beta(2) subunit
@en
P2093
B L Gerhardstein
M Bünemann
P304
P356
10.1074/JBC.274.48.33851
P407
P577
1999-11-26T00:00:00Z