Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. - Wikidata - wikimedia - TriplyDB

Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.

Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.

http://www.wikidata.org/entity/Q34752512

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Imaging alterations of cardiomyocyte cAMP microdomains in disease CaV1.2 signaling complexes in the heart L-type calcium channel targeting and local signalling in cardiac myocytes Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700 Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.Structural determinants of CaV1.3 L-type calcium channel gating.Cardiac T-Tubule Microanatomy and Function.The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.Regulation of voltage-gated calcium channels by proteolysis.Alterations of Ca(v)1.2 and 5-hydroxytryptamine in rat hearts after positional asphyxia.Analysis of AKAP7γ Dimerization.Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel Anchoring proteins as regulators of signaling pathways.Molecular evolution of A-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization.Evidence for redox sensing by a human cardiac calcium channel.Three-dimensional tracking and analysis of ion channel signals across dendritic arbors.Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response.Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150.Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.AKAP phosphatase complexes in the heart.Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases.Inherited calcium channelopathies in the pathophysiology of arrhythmias.Multilayered regulation of cardiac ion channels.L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization.Ion channel engineering: perspectives and strategies.L-type Ca2+ channels in heart and brain Proteolytic cleavage and PKA phosphorylation of α1C subunit are not required for adrenergic regulation of CaV1.2 in the heart.Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation.AKAP79 modulation of L-type channels involves disruption of intramolecular interactions in the CaV1.2 subunit Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression.β-adrenergic regulation of the L-type Ca2+ channel does not require phosphorylation of α1C Ser1700.Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel.Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.

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Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.

http://www.wikidata.org/entity/Q34752512

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Deletion of the distal C termi ...... ion and heart failure in vivo.

@ast

Deletion of the distal C termi ...... ion and heart failure in vivo.

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Deletion of the distal C termi ...... ion and heart failure in vivo.

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type

label

Deletion of the distal C termi ...... ion and heart failure in vivo.

@ast

Deletion of the distal C termi ...... ion and heart failure in vivo.

@en

Deletion of the distal C termi ...... ion and heart failure in vivo.

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prefLabel

Deletion of the distal C termi ...... ion and heart failure in vivo.

@ast

Deletion of the distal C termi ...... ion and heart failure in vivo.

@en

Deletion of the distal C termi ...... ion and heart failure in vivo.

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JBC.M110.175307

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Journal of Biological Chemistry

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Deletion of the distal C termi ...... ion and heart failure in vivo.

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Frank H Yu

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John P Clark

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Misty R Marshall

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Ruth E Westenbroek

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Todd Scheuer

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William A Catterall

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Ying Fu

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P2860

Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit

Structure and regulation of voltage-gated Ca2+ channels

Calcium fluxes involved in control of cardiac myocyte contraction

cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

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