Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7
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Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradationThe E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulumArkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signalingJab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradationArkadia amplifies TGF-beta superfamily signalling through degradation of Smad7Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cellsRoles of E3 ubiquitin ligases in cell adhesion and migration.Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.Discovery of putative oocyte quality markers by comparative ExacTag proteomicsDistinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.Ubiquitin-dependent regulation of TGFbeta signaling in cancerSmurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation.The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.WW Domain Containing Transcription Regulator regulates human conjunctiva epithelial cell proliferation via inhibiting TGFβ signaling pathway [corrected].The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer MetastasisRegulation of TGF-beta family signaling by E3 ubiquitin ligases.Regulating the stability of TGFbeta receptors and Smads.Repression of classical nuclear export by S-nitrosylation of CRM1.Degradation of activated protein kinases by ubiquitination.Regulation of TGF-beta signalling by protein phosphatases.Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.Role of Smads in TGFβ signaling.How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game.Yeast ubiquitin ligase Rsp5 contains nuclear localization and export signals.Regulation of TGF-β Family Signaling by Inhibitory Smads.The balance between acetylation and deacetylation controls Smad7 stability.Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.Identification of a nuclear export signal and protein interaction domains in deformed epidermal autoregulatory factor-1 (DEAF-1).Downregulation of TGF-beta receptor signalingPercutaneous gene therapy heals cranial defects.SMAD7 binds to SMURF1SMAD7:SMURF1 complex binds XPO1 (CRM1)SMAD7:SMURF1 complex is exported to the cytosolI-Smad competes with R-Smad1/5/8 for type I receptor
P2860
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P2860
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7
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2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@ast
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@en
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@nl
type
label
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@ast
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@en
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@nl
prefLabel
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@ast
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@en
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@nl
P2093
P2860
P356
P1476
Chromosomal region maintenance ...... factor-beta signaling by Smad7
@en
P2093
Kenichi Shinomiya
Kohei Miyazono
Kouichiro Goto
Takeshi Imamura
Toshihiro Sekimoto
Yoshihiro Yoneda
Yoshitaka Tajima
P2860
P304
P356
10.1074/JBC.M212663200
P407
P577
2003-03-21T00:00:00Z